Document Detail

Human placental lactogen (hPL) model for the normal pregnancy.
MedLine Citation:
PMID:  1754578     Owner:  NLM     Status:  MEDLINE    
This study includes 75 females with normal pregnancies, and presents individual cases of longitudinal series of human placental lactogen (hPL). Samples for hPL levels are taken during the period from gestational week 26 and until labour. A modified Gompertz equation is defined, characterized as growth at a continuously decreasing exponential rate, which finally plateaus in gestational week 36. This modified Gompertz equation adequately fitted individual hPL series. The work describes that a final hPL forecast for the normal pregnancy could be obtained in gestational week 30 using knowledge on maternal height and age, combined with a single hPL sample. The present model was applied in six pathological pregnancies with intrauterine growth retardation, and in all cases measured hPL levels were below the model estimate.
J Carl; M Christensen; O Mathiesen
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Placenta     Volume:  12     ISSN:  0143-4004     ISO Abbreviation:  Placenta     Publication Date:    1991 May-Jun
Date Detail:
Created Date:  1992-01-30     Completed Date:  1992-01-30     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8006349     Medline TA:  Placenta     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  289-98     Citation Subset:  IM    
Department of Oncology, Aalborg Sygehus Syd, Denmark.
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MeSH Terms
Analysis of Variance
Body Height
Fetal Growth Retardation / etiology
Hemoglobins / analysis
Longitudinal Studies
Maternal Age
Models, Biological
Placental Lactogen / biosynthesis*
Pregnancy / metabolism*
Pregnancy Trimester, Second
Pregnancy Trimester, Third
Regression Analysis
Smoking / adverse effects
Reg. No./Substance:
0/Hemoglobins; 9035-54-5/Placental Lactogen

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