Human placental extract treatment for nonalcoholic steatohepatitis nonresponsive to lifestyle intervention: a pilot study. | |
MedLine Citation:
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PMID: 25297827 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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AIM: No pharmacological therapies have been established for nonalcoholic steatohepatitis (NASH), which can lead to liver-related mortality. Human placental extract (HPE), which has anti-inflammatory effects, has been expected to be a promising treatment for chronic liver disease. This pilot study was conducted to evaluate the efficacy of HPE for biopsy-diagnosed NASH. METHODS: After a lifestyle intervention for 12 weeks, 10 subjects with abnormal ALT (>30 IU/L) and biopsy-proven NASH (NAFLD activity score [NAS] > 4) received intramuscular injections of HPE (Laennec) at a dose of 4 ml/day twice per week for 24 weeks, and seven of them underwent a second liver biopsy after the treatment. Liver biopsies were scored for NAS and fibrosis. Histological response was defined as a decrease of 2 points or more in NAS and no increase in fibrosis. RESULTS: Serum transaminase activities were significantly lower at 8 weeks compared to pre-treatment levels in 9 patients who continued treatment for 24 weeks. One patient refused to continue the treatment soon after starting therapies. In seven patients undergoing post-treatment biopsies, NAS (mean [SD]) mildly decreased from 5.29 [0.95] to 4.00 [1.83] without reaching statistical significance (p=0.078). Histological response was observed in all of 3 obese patients and in only one of 5 non-obese ones. No significant changes were observed in body mass index, lipid profiles, and diabetic control/insulin resistance. CONCLUSIONS: In NASH patients who received HPE treatment, significant reductions in serum liver enzymes were obtained after 8 weeks. Histological efficacy might be better in obese patients than in non-obese ones. |
Authors:
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Hideto Shimokobe; Yoshio Sumida; Saiyu Tanaka; Kohjiro Mori; Yoko Kitamura; Kohei Fukumoto; Akira Kakutani; Tomoyuki Ohno; Kazuyuki Kanemasa; Shunsuke Imai; Sawako Hibino; Toshikazu Yoshikawa |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2014-10-9 |
Journal Detail:
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Title: Hepatology research : the official journal of the Japan Society of Hepatology Volume: - ISSN: 1386-6346 ISO Abbreviation: Hepatol. Res. Publication Date: 2014 Oct |
Date Detail:
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Created Date: 2014-10-9 Completed Date: - Revised Date: 2014-10-10 |
Medline Journal Info:
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Nlm Unique ID: 9711801 Medline TA: Hepatol Res Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
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This article is protected by copyright. All rights reserved. |
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