| Human placental extract treatment for nonalcoholic steatohepatitis nonresponsive to lifestyle intervention: a pilot study. | |
MedLine Citation:
|
PMID: 25297827 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
AIM: No pharmacological therapies have been established for nonalcoholic steatohepatitis (NASH), which can lead to liver-related mortality. Human placental extract (HPE), which has anti-inflammatory effects, has been expected to be a promising treatment for chronic liver disease. This pilot study was conducted to evaluate the efficacy of HPE for biopsy-diagnosed NASH. METHODS: After a lifestyle intervention for 12 weeks, 10 subjects with abnormal ALT (>30 IU/L) and biopsy-proven NASH (NAFLD activity score [NAS] > 4) received intramuscular injections of HPE (Laennec) at a dose of 4 ml/day twice per week for 24 weeks, and seven of them underwent a second liver biopsy after the treatment. Liver biopsies were scored for NAS and fibrosis. Histological response was defined as a decrease of 2 points or more in NAS and no increase in fibrosis. RESULTS: Serum transaminase activities were significantly lower at 8 weeks compared to pre-treatment levels in 9 patients who continued treatment for 24 weeks. One patient refused to continue the treatment soon after starting therapies. In seven patients undergoing post-treatment biopsies, NAS (mean [SD]) mildly decreased from 5.29 [0.95] to 4.00 [1.83] without reaching statistical significance (p=0.078). Histological response was observed in all of 3 obese patients and in only one of 5 non-obese ones. No significant changes were observed in body mass index, lipid profiles, and diabetic control/insulin resistance. CONCLUSIONS: In NASH patients who received HPE treatment, significant reductions in serum liver enzymes were obtained after 8 weeks. Histological efficacy might be better in obese patients than in non-obese ones. |
Authors:
|
Hideto Shimokobe; Yoshio Sumida; Saiyu Tanaka; Kohjiro Mori; Yoko Kitamura; Kohei Fukumoto; Akira Kakutani; Tomoyuki Ohno; Kazuyuki Kanemasa; Shunsuke Imai; Sawako Hibino; Toshikazu Yoshikawa |
Related Documents
:
|
1696337 - Malignant pleural mesothelioma: a survival study. 8131537 - Assessment of operative risk in patients undergoing lung resection. importance of predi... 20591457 - Comparison of the effects of oral hydration and intravenous fluid replacement in adult ... 20298317 - Treatment of lobar atelectasis with bronchoscopically administered recombinant human de... 19228407 - The aprotinin saga and the risks of conducting meta-analyses on small randomised contro... 10228817 - Influence of vagal pyloric branches on gastric acid secretion and gastrointestinal moti... |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2014-10-9 |
Journal Detail:
|
Title: Hepatology research : the official journal of the Japan Society of Hepatology Volume: - ISSN: 1386-6346 ISO Abbreviation: Hepatol. Res. Publication Date: 2014 Oct |
Date Detail:
|
Created Date: 2014-10-9 Completed Date: - Revised Date: 2014-10-10 |
Medline Journal Info:
|
Nlm Unique ID: 9711801 Medline TA: Hepatol Res Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
|
This article is protected by copyright. All rights reserved. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: The effects of dexamethasone on the proliferation and apoptosis of human ovarian cancer cells induce...
Next Document: Mistic's membrane association and its assistance in overexpression of a human GPCR are independent p...