| Human placental IGF-I and IGF-II expression: correlating maternal and infant anthropometric variables and micronutrients at birth in the Pakistani population. | |
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MedLine Citation:
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PMID: 18624994 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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AIM: To correlate infant birth weight with maternal and infant biometric data, including the expression of placental IGF-I and IGF-II at birth, and levels of serum zinc and ferritin. METHODS: The data consisted of observations from 89 women from Karachi, Pakistan. Placental and cord blood samples were taken immediately following delivery and were subsequently divided into two groups, small and large for gestational age (SGA and LGA). Results: The mean birth weight was 2.79 kg; the prevalence of SGA being 13.4% (< or =10th percentile); the prevalence of LGA being 23.6% (> or =90th percentile). Placental IGF-I and IGF-II mRNA expression was greater in the LGA group (p < 0.05). Furthermore, a significant correlation was noted between infant birth weight and maternal anthropometric parameters (p < 0.01). Cord zinc levels were also significantly higher in the LGA group (p < 0.05). CONCLUSION: Maternal anthropometry, along with placental IGF-I and IGF-II mRNA levels, correlated significantly with infant birth weight suggesting the importance of these growth factors for birth weight outcomes. The higher zinc levels in the LGA group also suggest the importance of this micronutrient in foetal growth. Our results suggest that growth problems have a multifactorial aetiology arising from within the infant rather than due to maternal constraint alone. |
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Authors:
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S K Akram; M Akram; Z A Bhutta; O Soder |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2008-07-10 |
Journal Detail:
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Title: Acta paediatrica (Oslo, Norway : 1992) Volume: 97 ISSN: 0803-5253 ISO Abbreviation: Acta Paediatr. Publication Date: 2008 Oct |
Date Detail:
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Created Date: 2008-09-10 Completed Date: 2009-01-16 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9205968 Medline TA: Acta Paediatr Country: Norway |
Other Details:
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Languages: eng Pagination: 1443-8 Citation Subset: IM |
Affiliation:
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Department of Women and Children's Health, Karolinska Hospital, Stockholm, Sweden. shahzad.akram@ki.se |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Anthropometry Biological Markers Birth Weight* Female Ferritins / blood Humans Infant Infant Welfare Infant, Newborn Insulin-Like Growth Factor I / analysis* Insulin-Like Growth Factor II / analysis* Maternal Welfare* Micronutrients* Pakistan / epidemiology Placenta / chemistry* Pregnancy Prevalence Prospective Studies Zinc / blood |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/Micronutrients; 67763-96-6/Insulin-Like Growth Factor I; 67763-97-7/Insulin-Like Growth Factor II; 7440-66-6/Zinc; 9007-73-2/Ferritins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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