Document Detail

Human placental 17 beta-estradiol dehydrogenase: enzymatic activity in the last weeks of pregnancy and electrophoretic data.
MedLine Citation:
PMID:  1806469     Owner:  NLM     Status:  MEDLINE    
A specific electrophoretic method for human placental 17 beta-estradiol dehydrogenase (17-HSD; EC has been performed and a sample of about 180 placentae from Italian women has been examined. A common phenotype and only one electrophoretic variant have been observed. Also 17-HSD activity has been tested. A statistically significant negative correlation has been found between 17-HSD activity and both gestational age and birth weight in the last weeks of gestation in a group of at term newborns with weight appropriate for date. This reduction in enzymatic activity is in good agreement with the data on estrone and estradiol which both show a declining rate of increase in the last weeks of pregnancy.
R M Corbo; R Scacchi; M Lenci
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Hormone research     Volume:  35     ISSN:  0301-0163     ISO Abbreviation:  Horm. Res.     Publication Date:  1991  
Date Detail:
Created Date:  1992-05-14     Completed Date:  1992-05-14     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0366126     Medline TA:  Horm Res     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  151-4     Citation Subset:  IM    
Department of Genetics and Molecular Biology, University la Sapienza, Rome, Italy.
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MeSH Terms
Birth Weight
Electrophoresis, Agar Gel
Estradiol Dehydrogenases / isolation & purification,  metabolism*
Gestational Age
Infant, Newborn
Placenta / enzymology*
Pregnancy Trimester, Third
Regression Analysis
Reg. No./Substance:
EC Dehydrogenases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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