Document Detail


Human pilot studies reveal the potential of a vitronectin: growth factor complex as a treatment for chronic wounds.
MedLine Citation:
PMID:  21914133     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Several different advanced treatments have been used to improve healing in chronic wounds, but none have shown sustained success. The application of topical growth factors (GFs) has displayed some potential, but the varying results, high doses and high costs have limited their widespread adoption. Many treatments have ignored the evidence that wound healing is driven by interactions between extracellular matrix proteins and GFs, not just GFs alone. We report herein that a clinical Good Manufacturing Practice-grade vitronectin:growth factor (cVN:GF) complex is able to stimulate functions relevant to wound repair in vitro, such as enhanced cellular proliferation and migration. Furthermore, we assessed this complex as a topical wound healing agent in a single-arm pilot study using venous leg ulcers, as well as several 'difficult to heal' case studies. The cVN:GF complex was safe and re-epithelialisation was observed in all but 1 of the 30 patients in the pilot study. In addition, the case studies show that this complex may be applied to several ulcer aetiologies, such as venous leg ulcers, diabetic foot ulcers and pressure ulcers. These findings suggest that further evaluation is warranted to determine whether the cVN:GF complex may be an effective topical treatment for chronic wounds.
Authors:
Zee Upton; Hilary J Wallace; Gary K Shooter; Derek R van Lonkhuyzen; Sim Yeoh-Ellerton; Erin A Rayment; Jacqui M Fleming; Daniel Broszczak; Douglas Queen; R Gary Sibbald; David I Leavesley; Michael C Stacey
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Publication Detail:
Type:  JOURNAL ARTICLE    
Journal Detail:
Title:  International wound journal     Volume:  8     ISSN:  1742-481X     ISO Abbreviation:  -     Publication Date:  2011 Oct 
Date Detail:
Created Date:  2011-9-14     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101230907     Medline TA:  Int Wound J     Country:  -    
Other Details:
Languages:  ENG     Pagination:  522-532     Citation Subset:  -    
Copyright Information:
© 2011 The Authors. © 2011 Blackwell Publishing Ltd and Medicalhelplines.com Inc.
Affiliation:
Z Upton, PhD, Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Queensland, Australia HJ Wallace, PhD, Burn Injury Research Unit, The University of Western Australia, Fremantle, Western Australia, Australia GK Shooter, PhD, Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Queensland, Australia DR van Lonkhuyzen, PhD, Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Queensland, Australia S Yeoh-Ellerton, PhD, Fremantle Hospital, The University of Western Australia, Fremantle, Western Australia, Australia EA Rayment, PhD, Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Queensland, Australia JM Fleming, BAppSc (Hons), Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Queensland, Australia D Broszczak, BAppSc (Hons), Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Queensland, Australia D Queen, PhD, MBA, Unit 23, Wound Clinic, Suite 210, 1077 North Service Road, Mississauga, ON, Canada RG Sibbald, MD, FRCPC, MEd, Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada DI Leavesley, PhD, Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Queensland, Australia MC Stacey, DS, FRACS, Fremantle Hospital, The University of Western Australia, Fremantle, Western Australia, Australia.
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