Document Detail

Human periprostatic white adipose tissue is rich in stromal progenitor cells and a potential source of prostate tumor stroma.
MedLine Citation:
PMID:  23038706     Owner:  NLM     Status:  MEDLINE    
A body of growing evidence now implicates white adipose tissue as a relevant source of stromal progenitor cells recruited to the tumor microenvironment to form supportive tumor stroma. While the role of periprostatic (PP) adipose tissue in prostate cancer progression has been barely appreciated, we sought to determine the progenitor cell population in PP adipose tissue and the association with prostate cancer. We isolated and characterized CD31(-)CD34(+)CD45(-)CD146(-) progenitor cells (adipose-derived stem cells [ASC]) in paired samples of PP and preperitoneal visceral adipose tissue from prostate tissue and peripheral blood mononuclear cells of prostate cancer and nodular prostatic hyperplasia patients. ASC were quantified by flow cytometry and confirmed through target gene expression. Here we show a significantly higher amount of ASC in PP than in visceral adipose tissue, independent of body mass index and prostatic disease. In the prostate, ASC are increased in cancer compared with prostatic nodular hyperplasia patients. Concordantly, adipsin gene (CFD) expression, which is known to be up-regulated in adipose stem cells, was overexpressed in PP adipose tissue, in the prostate of cancer patients and in prostate CD31(-)CD34(+)CD45(-)CD146(-) sorted cells. ASC were found at higher levels in the blood of prostate cancer patients simultaneously overweight/obese. Present findings indicate that PP adipose tissue is a reservoir of progenitor cells with the potential to migrate towards prostate tumors, although its clinical significance merits further evaluation.
Ricardo Ribeiro; Cátia Monteiro; Ricardo Silvestre; Angela Castela; Helena Coutinho; Avelino Fraga; Paulo Príncipe; Carlos Lobato; Carla Costa; Anabela Cordeiro-da-Silva; José Manuel Lopes; Carlos Lopes; Rui Medeiros
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2012-10-04
Journal Detail:
Title:  Experimental biology and medicine (Maywood, N.J.)     Volume:  237     ISSN:  1535-3699     ISO Abbreviation:  Exp. Biol. Med. (Maywood)     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-11-01     Completed Date:  2013-02-05     Revised Date:  2013-09-26    
Medline Journal Info:
Nlm Unique ID:  100973463     Medline TA:  Exp Biol Med (Maywood)     Country:  England    
Other Details:
Languages:  eng     Pagination:  1155-62     Citation Subset:  IM    
Molecular Oncology Group-CI, Portuguese Institute of Oncology, Rua Dr. António Bernardino Almeida, Porto, Portugal.
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MeSH Terms
Adipose Tissue, White / metabolism,  pathology*
Cell Differentiation
Complement Factor D / metabolism
Disease Progression
Flow Cytometry
Middle Aged
Prostate / metabolism,  pathology
Prostatic Hyperplasia / metabolism,  pathology*
Prostatic Neoplasms / metabolism,  pathology*
Stem Cells / metabolism,  pathology*
Stromal Cells / metabolism,  pathology
Reg. No./Substance:
EC Factor D; EC factor D, human

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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