Document Detail


Human pathologic correlation with PET in ischemic and nonischemic cardiomyopathy.
MedLine Citation:
PMID:  8418269     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
To assess the correlation between myocardial perfusion, metabolism and histologic findings in patients with cardiomyopathy, we evaluated myocardial perfusion and metabolism using positron emission tomography (PET) with 13NH3 (ammonia) and 18FDG (fluoro-2-deoxy-glucose) in nine patients prior to undergoing orthotopic cardiac transplantation. Four patients had ischemic cardiomyopathy (ISCM) and five had nonischemic cardiomyopathy (NISCM). Normalized circumferential profile analyses of representative mid-ventricular perfusion and metabolism PET images were performed for each patient. A corresponding mid-ventricular transaxial slice was obtained from the formalin fixed explanted heart and processed for routine histology. Hematoxylin-eosin stained and Masson trichrome stained sections were evaluated and the percentage of the slice occupied by infarct was determined planimetrically at 10-degree intervals in a circumferential manner. A significant correlation was found between circumferential normalized PET count density profile of perfusion and metabolism in both the ischemic and nonischemic groups (ISCM range r = 0.65-0.75; NISCM range, r = 0.70-0.87). Furthermore, there was a correlation in the ISCM group between the extent of matched perfusion/metabolism defects and transmural infarct involvement (r = 0.66-0.88). PET perfusion and metabolic data closely correlate with pathologic infarction in human hearts of ischemic cardiomyopathy patients.
Authors:
J J Berry; J M Hoffman; C Steenbergen; J A Baker; C Floyd; P Van Trigt; M W Hanson; R E Coleman
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of nuclear medicine : official publication, Society of Nuclear Medicine     Volume:  34     ISSN:  0161-5505     ISO Abbreviation:  J. Nucl. Med.     Publication Date:  1993 Jan 
Date Detail:
Created Date:  1993-02-03     Completed Date:  1993-02-03     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0217410     Medline TA:  J Nucl Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  39-47     Citation Subset:  IM    
Affiliation:
Department of Medicine, Duke University Medical Center, Durham, NC 27710.
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MeSH Terms
Descriptor/Qualifier:
Adult
Cardiomyopathies / etiology,  pathology*,  radionuclide imaging*,  surgery
Coronary Circulation
Female
Heart / radionuclide imaging*
Heart Transplantation
Humans
Male
Middle Aged
Myocardial Ischemia / complications*
Myocardium / pathology*
Tomography, Emission-Computed*
Grant Support
ID/Acronym/Agency:
P50-HL17760/HL/NHLBI NIH HHS

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