Document Detail

Human parvovirus B19 infection and unbalanced translocation in a case of hydrops fetalis.
MedLine Citation:
PMID:  8052566     Owner:  NLM     Status:  MEDLINE    
In a case of hydrops fetalis, serological examination showed a recent maternal human parvovirus B19 infection. Amniocentesis revealed a unique unbalanced translocation between chromosomes 3 and 11 of the fetus. The mother proved to have a balanced reciprocal translocation between chromosomes 3 and 11. A grossly macerated hydropic male fetus was delivered with a flat nose and low implanted deformed ears. Histopathological examination revealed nuclear inclusion bodies in fetal erythroid cells, confirming human parvovirus B19 infection. Parvovirus B19 DNA was demonstrated by in situ hybridization in the nuclei of heart muscle cells. Our finding of two different disorders in one case illustrates the importance of a complete evaluation of every case of hydrops fetalis, especially concerning counselling on the outcome of future pregnancies. The human parvovirus B19 infection will not recur due to the acquired immunity of the mother, whereas the balanced reciprocal translocation will endanger future pregnancies.
C Willekes; F J Roumen; A M van Elsacker-Niele; H T Weiland; C Vermey-Keers; J H van Krieken; C E De Die-Smulders; G J Hamers; G P Vaes-Peters
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Prenatal diagnosis     Volume:  14     ISSN:  0197-3851     ISO Abbreviation:  Prenat. Diagn.     Publication Date:  1994 Mar 
Date Detail:
Created Date:  1994-09-08     Completed Date:  1994-09-08     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8106540     Medline TA:  Prenat Diagn     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  181-5     Citation Subset:  IM    
Department of Obstetrics, School of Midwifery, Kerkrade, The Netherlands.
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MeSH Terms
Chromosomes, Human, Pair 11*
Chromosomes, Human, Pair 3*
Hydrops Fetalis / genetics*,  microbiology
Parvoviridae Infections / genetics*
Parvovirus B19, Human*
Translocation, Genetic*

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