| Human papillomavirus type 77 E7 protein is a weak deregulator of cell cycle. | |
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MedLine Citation:
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PMID: 16650526 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Human Papillomavirus type 77 is a skin type found in non-melanoma skin cancers of immuno-compromised individuals. Although, the HPV77 E6 oncoprotein has been well studied, nothing is known about E7. Studies on mucosal HPV types (e.g. HPV16) showed that E7 deregulates the cell cycle by binding to and promoting degradation of retinoblastoma protein (pRb). Here, we characterized the impact of HPV77 E7 on the cell cycle. We observed that HPV77 E7 associated with pRb with a lower affinity than HPV16 E7, promoting weakly its degradation. Although, HPV16 E7 led to cellular proliferation and accumulation of the cell cycle inhibitor p16(INK4a), both events were not clearly observed in HPV77 E7 cells. Together, these data indicate that HPV77 E7 does not efficiently deregulate the cell cycle, in contrast to several E7s of mucosal HPV types. |
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Authors:
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Mariam Mansour; Majid Touka; Adriana Malena; Cesare Indiveri; Wen Dong; Ilaria Gionfriddo; Rosita Accardi; Angelo Paradiso; Bakary S Sylla; Anne-Sophie Gabet; Massimo Tommasino |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2006-05-02 |
Journal Detail:
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Title: Cancer letters Volume: 246 ISSN: 0304-3835 ISO Abbreviation: Cancer Lett. Publication Date: 2007 Feb |
Date Detail:
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Created Date: 2006-12-26 Completed Date: 2007-04-19 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7600053 Medline TA: Cancer Lett Country: Ireland |
Other Details:
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Languages: eng Pagination: 274-81 Citation Subset: IM |
Affiliation:
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International Agency for Research on Cancer, World Health Organization, Lyon, France. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cell Cycle / genetics, physiology* Cells, Cultured Cyclin-Dependent Kinase Inhibitor p16 / genetics, metabolism Gene Expression Genetic Vectors / genetics Humans Immunoblotting Mice NIH 3T3 Cells Oncogene Proteins, Viral / genetics, metabolism Papillomavirus E7 Proteins / genetics, metabolism* Protein Binding Retinoblastoma Protein / genetics, metabolism Reverse Transcriptase Polymerase Chain Reaction Transfection |
| Chemical | |
Reg. No./Substance:
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0/Cyclin-Dependent Kinase Inhibitor p16; 0/Oncogene Proteins, Viral; 0/Papillomavirus E7 Proteins; 0/Retinoblastoma Protein; 0/oncogene protein E7, Human papillomavirus type 16 |
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