Document Detail


Human papillomavirus type 52 polymorphism and high-grade lesions of the uterine cervix.
MedLine Citation:
PMID:  23015309     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
The association between polymorphism of human papillomavirus type 52 (HPV52) andhigh-grade cervical intraepithelial neoplasia (CIN2,3) was investigated in Canadianwomen. HPV-52-positive endocervical specimens collected from 216 women selectedfrom a total of 3614 participants recruited in two case-control and two cohort studiesconducted in Canada were further analyzed by PCR-sequencing of the LCR and E6 gene. Seventy-five participants did not have CIN, 21 had low-grade CIN (CIN1), 64 had CIN2,3, 7 had invasive cervical cancer and the diagnosis was unknown for 49 women. Overall, 34 non-prototypic variants in the LCR and 16 non-prototypic variants in E6 ere identified. Variant MTL-52-LCR-02 was detected more frequently in women with ancer (28.6%, 95% (confidence interval) CI 7.6%-64.8%) than in women without cancer or CIN2,3 (0%, 95% CI 0.0%-9.2%; p=0.015). CIN2,3 risk was significantly associated with a deletion at nucleotide position 7695 in the LCR (OR 5.7, 95% CI 1.2-27.9), the T7744C variation in the LCR (OR 8.3, 95% CI 1.1-61.0), and the K93R variation in E6 (OR 9.5, 95% CI 1.3-68.9), after adjusting for age, ethnicity, detection f PV16 or 18, and study site. The deletion resulted in the loss of a binding site for the human activator AP-1 while the T7744C variation resulted in the addition of a binding site for the cellular transcription factor Oct-1. These findings indicate that HPV52 polymorphism influences risk of CIN-2,3 and possibly invasive cancer. © 2012 Wiley Periodicals, Inc.
Authors:
Aurélie Fomentin; Jacques Archambault; Anita Koushik; Harriet Richardson; Paul Brassard; Eduardo L Franco; Francois Coutlée
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-9-27
Journal Detail:
Title:  International journal of cancer. Journal international du cancer     Volume:  -     ISSN:  1097-0215     ISO Abbreviation:  Int. J. Cancer     Publication Date:  2012 Sep 
Date Detail:
Created Date:  2012-9-27     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0042124     Medline TA:  Int J Cancer     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 UICC.
Affiliation:
1Centre de Recherche et Département de Microbiologie Médicale et Infectiologie,Centre Hospitalier de l'Université de Montréal (CHUM), Université de Montréal, Qué.,Canada.
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