| Human papillomavirus type 52 polymorphism and high-grade lesions of the uterine cervix. | |
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MedLine Citation:
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PMID: 23015309 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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The association between polymorphism of human papillomavirus type 52 (HPV52) andhigh-grade cervical intraepithelial neoplasia (CIN2,3) was investigated in Canadianwomen. HPV-52-positive endocervical specimens collected from 216 women selectedfrom a total of 3614 participants recruited in two case-control and two cohort studiesconducted in Canada were further analyzed by PCR-sequencing of the LCR and E6 gene. Seventy-five participants did not have CIN, 21 had low-grade CIN (CIN1), 64 had CIN2,3, 7 had invasive cervical cancer and the diagnosis was unknown for 49 women. Overall, 34 non-prototypic variants in the LCR and 16 non-prototypic variants in E6 ere identified. Variant MTL-52-LCR-02 was detected more frequently in women with ancer (28.6%, 95% (confidence interval) CI 7.6%-64.8%) than in women without cancer or CIN2,3 (0%, 95% CI 0.0%-9.2%; p=0.015). CIN2,3 risk was significantly associated with a deletion at nucleotide position 7695 in the LCR (OR 5.7, 95% CI 1.2-27.9), the T7744C variation in the LCR (OR 8.3, 95% CI 1.1-61.0), and the K93R variation in E6 (OR 9.5, 95% CI 1.3-68.9), after adjusting for age, ethnicity, detection f PV16 or 18, and study site. The deletion resulted in the loss of a binding site for the human activator AP-1 while the T7744C variation resulted in the addition of a binding site for the cellular transcription factor Oct-1. These findings indicate that HPV52 polymorphism influences risk of CIN-2,3 and possibly invasive cancer. © 2012 Wiley Periodicals, Inc. |
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Authors:
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Aurélie Fomentin; Jacques Archambault; Anita Koushik; Harriet Richardson; Paul Brassard; Eduardo L Franco; Francois Coutlée |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-9-27 |
Journal Detail:
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Title: International journal of cancer. Journal international du cancer Volume: - ISSN: 1097-0215 ISO Abbreviation: Int. J. Cancer Publication Date: 2012 Sep |
Date Detail:
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Created Date: 2012-9-27 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0042124 Medline TA: Int J Cancer Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2012 UICC. |
Affiliation:
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1Centre de Recherche et Département de Microbiologie Médicale et Infectiologie,Centre Hospitalier de l'Université de Montréal (CHUM), Université de Montréal, Qué.,Canada. |
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