Document Detail

Human papillomavirus type 16 DNA in anal cancers from six different countries.
MedLine Citation:
PMID:  1648029     Owner:  NLM     Status:  MEDLINE    
An association between anal squamous cell carcinoma and human papillomavirus (HPV) type 16 DNA has been documented in the UK. If HPV type 16 is an important aetiological factor in the development of this tumour it would be expected to occur in anal cancer tissues from other parts of the world. In this study a series of 173 anal squamous cell carcinoma tissue samples from five centres around the world have been examined by DNA hybridisation for HPV type 16 DNA sequences. HPV type 16 DNA was found in 50 of 173 (29%) of these. The prevalence of HPV associated anal squamous cell carcinoma was significantly lower in tissue from India and South Africa than in the Swiss, Polish, or Brazilian samples. HPV associated anal squamous cell carcinoma does occur in other countries and further investigations of the prevalence of these tumours in association with other HPV types are required.
J H Scholefield; I B Kerr; N A Shepherd; K J Miller; R Bloomfield; J M Northover
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Gut     Volume:  32     ISSN:  0017-5749     ISO Abbreviation:  Gut     Publication Date:  1991 Jun 
Date Detail:
Created Date:  1991-08-02     Completed Date:  1991-08-02     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  2985108R     Medline TA:  Gut     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  674-6     Citation Subset:  AIM; IM    
Imperial Cancer Research Fund, Colorectal Unit, St Mark's Hospital, London.
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MeSH Terms
Anus Neoplasms / chemistry*,  microbiology
Base Sequence
Carcinoma, Squamous Cell / chemistry*,  microbiology
DNA, Viral / analysis*
Molecular Sequence Data
Papillomaviridae / genetics*,  isolation & purification
Polymerase Chain Reaction
South Africa
Reg. No./Substance:
0/DNA, Viral

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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