| Human papillomavirus-related diseases: oropharynx cancers and potential implications for adolescent HPV vaccination. | |
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MedLine Citation:
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PMID: 18809146 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Molecular and epidemiological data now support an etiologic role for oncogenic human papillomavirus (HPV) in oral cancers in women and men. Recent studies have demonstrated an increase in the incidence of HPV-associated oral cancers in the United States. Moreover, the incidence rates for these cancers are higher in men than women. Oral HPV infections acquired through oral sex appear to be the principal risk factor for HPV-associated oral cancers. Despite reports in the popular press that the prevalence of oral sexual behaviors is increasing in the adolescent population, trends in these behaviors over time are largely unavailable. However, data indicate that oral-genital contact is frequently practiced among adolescents; adolescents do not typically consider this a risky behavior. The majority of oral cancers (approximately 90%) caused by HPV are identified as HPV 16 positive. Therefore, HPV-associated oral cancers could be prevented by a prophylactic vaccine if the vaccine were demonstrated to be capable of preventing oral HPV 16 infection. These findings have created new potential opportunities for the primary prevention of oral cancers. |
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Authors:
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Maura L Gillison |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: The Journal of adolescent health : official publication of the Society for Adolescent Medicine Volume: 43 ISSN: 1879-1972 ISO Abbreviation: J Adolesc Health Publication Date: 2008 Oct |
Date Detail:
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Created Date: 2008-09-23 Completed Date: 2008-11-03 Revised Date: 2011-07-25 |
Medline Journal Info:
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Nlm Unique ID: 9102136 Medline TA: J Adolesc Health Country: United States |
Other Details:
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Languages: eng Pagination: S52-60 Citation Subset: IM |
Affiliation:
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The Johns Hopkins Medical Institutions, Baltimore, Maryland 21231, USA. gillima@jhmi.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adolescent Behavior Adult Female Human papillomavirus 16 / immunology, isolation & purification Humans Incidence Male Oropharyngeal Neoplasms / epidemiology, prevention & control*, virology* Papillomavirus Infections / complications*, epidemiology, prevention & control* Papillomavirus Vaccines / administration & dosage*, immunology Sex Factors Sexual Behavior United States / epidemiology |
| Grant Support | |
ID/Acronym/Agency:
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DE016631-02/DE/NIDCR NIH HHS; R01 DE016631-04/DE/NIDCR NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Papillomavirus Vaccines |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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