Document Detail


Human papillomavirus prevalence in postradiotherapy uterine cervical carcinoma patients: correlation with recurrence of the disease.
MedLine Citation:
PMID:  16803484     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
To understand the role of human papillomavirus (HPV) in recurrence of uterine cervical cancer (CA-CX) after radiotherapy, we have analyzed the HPV prevalence in the exfoliated cells of 56 patients and their corresponding plasma. HPV DNA was detected in exfoliated cells of 78% (44/56) patients (HPV-16, 68%; HPV-18, 14%; HPV-X [other than 16, 18], 11%; and mixed infection of HPV-16 and HPV-18 in three cases). HPV DNA in plasma was present in only 25% (11/44) of the HPV-positive exfoliated cells (positive predictive value, 100%; negative predictive value, 27%) with concordance in HPV types. The recurrence of the disease was significantly associated with the presence of HPV in the exfoliated cell (P= 0.01) and plasma (P= 0.007) as well as high viral load in the exfoliated cell (P= 0.0002). Kaplan-Meier disease-free estimates have also shown the significant association between HPV prevalence in plasma and recurrence of the disease (P= 0.045). Thus, it indicates that in postradiotherapy CA-CX patients, the high viral load in the exfoliated cell as well as HPV presence in the plasma samples could be used in early detection of the patients at increased risk for disease recurrence and progression.
Authors:
R K Singh; S Maulik; S Mitra; R K Mondal; P S Basu; S Roychowdhury; C K Panda
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Publication Detail:
Type:  Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  International journal of gynecological cancer : official journal of the International Gynecological Cancer Society     Volume:  16     ISSN:  1048-891X     ISO Abbreviation:  Int. J. Gynecol. Cancer     Publication Date:    2006 May-Jun
Date Detail:
Created Date:  2006-06-28     Completed Date:  2007-02-27     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9111626     Medline TA:  Int J Gynecol Cancer     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1048-54     Citation Subset:  IM    
Affiliation:
Departments of Oncogene Regulation and Gynaecology Oncology, Chittaranjan National Cancer Institute, 37 S.P. Mukherjee Road, Kolkata 700-026, India.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aftercare / statistics & numerical data
Aged
Carcinoma / radiotherapy*,  virology*
Female
Humans
Middle Aged
Neoplasm Recurrence, Local / epidemiology*
Papillomaviridae / isolation & purification*
Papillomavirus Infections / blood,  complications,  epidemiology*
Prevalence
Sensitivity and Specificity
Survival Analysis
Uterine Cervical Neoplasms / mortality,  radiotherapy*,  virology*
Vaginal Smears
Viral Load / statistics & numerical data

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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