| Human papillomavirus and p16 expression in inverted papillomas of the urinary bladder. | |
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MedLine Citation:
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PMID: 20036459 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Human Papillomaviruses (HPVs) have been found in association with benign and malignant growth of epithelia. The cell cycle inhibitor p16(Ink4a) has been shown to be overexpressed in HPV-positive cervical pre-malignant and malignant lesions, probably as a result of pRB targeting by the viral E7 protein. Inverted papillomas of the urinary bladder are epithelial tumors considered to be of benign nature. In this report we analyze the expression of p16(Ink4a) and the presence of HPV sequences in inverted papillomas and in non-tumoral bladder controls. Our results show no association of HPV infection and inverted papillomas. Further, no correlation between p16 overexpression and HPV positivity was found. We conclude that HPV does not play an indispensable role in the development of urinary bladder inverted papillomas and that overexpression of p16(Ink4a) does not correlate with HPV infection in these tumors. |
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Authors:
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Victor E Gould; Markus Schmitt; Svetlana Vinokurova; Vijaya B Reddy; Pincas Bitterman; Angel Alonso; Paolo Gattuso |
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Publication Detail:
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Type: Journal Article Date: 2009-12-29 |
Journal Detail:
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Title: Cancer letters Volume: 292 ISSN: 1872-7980 ISO Abbreviation: Cancer Lett. Publication Date: 2010 Jun |
Date Detail:
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Created Date: 2010-04-20 Completed Date: 2010-05-04 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7600053 Medline TA: Cancer Lett Country: Ireland |
Other Details:
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Languages: eng Pagination: 171-5 Citation Subset: IM |
Copyright Information:
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Copyright 2009 Elsevier Ireland Ltd. All rights reserved. |
Affiliation:
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Department of Pathology, Rush University, Chicago, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Alphapapillomavirus
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genetics,
isolation & purification* Cyclin-Dependent Kinase Inhibitor p16 / metabolism* Genotype Humans Immunohistochemistry Papilloma / metabolism*, virology* Polymerase Chain Reaction Urinary Bladder Neoplasms / metabolism*, pathology, virology* |
| Chemical | |
Reg. No./Substance:
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0/Cyclin-Dependent Kinase Inhibitor p16 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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