Document Detail

Human papillomavirus and p16 expression in inverted papillomas of the urinary bladder.
MedLine Citation:
PMID:  20036459     Owner:  NLM     Status:  MEDLINE    
Human Papillomaviruses (HPVs) have been found in association with benign and malignant growth of epithelia. The cell cycle inhibitor p16(Ink4a) has been shown to be overexpressed in HPV-positive cervical pre-malignant and malignant lesions, probably as a result of pRB targeting by the viral E7 protein. Inverted papillomas of the urinary bladder are epithelial tumors considered to be of benign nature. In this report we analyze the expression of p16(Ink4a) and the presence of HPV sequences in inverted papillomas and in non-tumoral bladder controls. Our results show no association of HPV infection and inverted papillomas. Further, no correlation between p16 overexpression and HPV positivity was found. We conclude that HPV does not play an indispensable role in the development of urinary bladder inverted papillomas and that overexpression of p16(Ink4a) does not correlate with HPV infection in these tumors.
Victor E Gould; Markus Schmitt; Svetlana Vinokurova; Vijaya B Reddy; Pincas Bitterman; Angel Alonso; Paolo Gattuso
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Publication Detail:
Type:  Journal Article     Date:  2009-12-29
Journal Detail:
Title:  Cancer letters     Volume:  292     ISSN:  1872-7980     ISO Abbreviation:  Cancer Lett.     Publication Date:  2010 Jun 
Date Detail:
Created Date:  2010-04-20     Completed Date:  2010-05-04     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7600053     Medline TA:  Cancer Lett     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  171-5     Citation Subset:  IM    
Copyright Information:
Copyright 2009 Elsevier Ireland Ltd. All rights reserved.
Department of Pathology, Rush University, Chicago, USA.
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MeSH Terms
Alphapapillomavirus / genetics,  isolation & purification*
Cyclin-Dependent Kinase Inhibitor p16 / metabolism*
Papilloma / metabolism*,  virology*
Polymerase Chain Reaction
Urinary Bladder Neoplasms / metabolism*,  pathology,  virology*
Reg. No./Substance:
0/Cyclin-Dependent Kinase Inhibitor p16

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