Document Detail


Human papillomavirus localization in cervical adenocarcinoma and adenosquamous carcinoma using in situ polymerase chain reaction: review of the literature of human papillomavirus detection in these carcinomas.
MedLine Citation:
PMID:  16704493     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Many studies have suggested that human papillomavirus (HPV) infection plays an important role in the carcinogenesis of the cervical adenocarcinoma. However, the prevalence of HPV infection in cervical adenocarcinoma and adenosquamous carcinoma varies among the studies. Cervical adenocarcinoma (24 cases) and adenosquamous carcinoma (16 cases), including the underlying non-neoplastic epithelium were examined for HPV-DNA using in situ polymerase chain reaction (PCR), which enabled visualization of the localization on a glass slide. In adenocarcinoma, HPV-DNA was found in 13 cases (54%) and in eight cases in underlying non-neoplastic epithelium, resulting in a total of 21 positive cases (88%). In adenosquamous carcinoma, HPV-DNA was detected in 12 cases (75%) and and the HPV-DNA localization of each component was pure adenocarcinoma, 28.6%; mixed, 54.5%; and pure squamous cell carcinoma, 83.3%. In the underlying non-neoplastic epithelium, HPV-DNA was found more frequently in the squamous epithelium (73.3%) than the cervical glands (6.3%). In conclusion, HPV-DNA was detected in 54% of adenocarcinoma, and the rate was elevated by HPV localization in the underlying non-neoplastic epithelium. HPV infection in the underlying squamous epithelium might be related to the carcinogenesis, even in cervical adenocarcinoma. HPV-DNA localization was different in each component of adenosquamous carcinoma.
Authors:
Kanako Ogura; Kazuhisa Ishi; Toshiharu Matsumoto; Katsunari Kina; Michio Nojima; Koichi Suda
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Pathology international     Volume:  56     ISSN:  1320-5463     ISO Abbreviation:  Pathol. Int.     Publication Date:  2006 Jun 
Date Detail:
Created Date:  2006-05-17     Completed Date:  2006-08-10     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9431380     Medline TA:  Pathol Int     Country:  Australia    
Other Details:
Languages:  eng     Pagination:  301-8     Citation Subset:  IM    
Affiliation:
Department of Pathology (I), School of Medicine, Juntendo University, Tokyo, Japan. kanako-o@med.juntendo.ac.jp
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MeSH Terms
Descriptor/Qualifier:
Adenocarcinoma / pathology,  virology*
Adult
Aged
Carcinoma, Adenosquamous / pathology,  virology*
DNA Probes, HPV
DNA, Viral / analysis
Female
Humans
Middle Aged
Papillomaviridae / genetics,  isolation & purification*
Papillomavirus Infections / pathology*
Polymerase Chain Reaction
Uterine Cervical Neoplasms / pathology,  virology*
Chemical
Reg. No./Substance:
0/DNA Probes, HPV; 0/DNA, Viral

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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