Document Detail

Human papillomavirus infection in "young" versus "old" patients with squamous cell carcinoma of the head and neck.
MedLine Citation:
PMID:  11002318     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Human papillomavirus (HPV) represents a potential risk factor for squamous cell cancer of the head and neck (SCCHN). We evaluated the prevalence of HPV DNA in patients with SCCHN diagnosed at the University of Michigan from 1994-1996. METHODS: Patients were stratified by age at diagnosis as "young" (<50 years; median, 39) or "old" (>50 years; median, 66). Fourteen "young" and 14 "old" were matched for tumor site, and 4 additional "old" patients were included. Specimens were analyzed by polymerase chain reaction for HPV DNA using 2 sets of consensus primers. HPV sequences were confirmed by Southern blot hybridization and typed with type-specific probes. RESULTS: Overall, 15 of 32 (46.9%) samples contained HPV sequences. HPV 16 was detected in 9 of 15 (60%), HPV-18 in 1 of 15 (6.6%), and 5 of 15 (33.3%) remained untyped by multiple methods. When stratified, 7 of 14 (50%) "young" were HPV-positive compared with 8 of 18 (44.4%) "old" (p =.76). Survival in patients with HPV-positive SCCHN was significantly longer than that for HPV-negative patients. CONCLUSIONS: The incidence of HPV in "young" versus "old" is not significantly different, suggesting similar roles for both groups. Patients with HPV-positive tumors may have a survival advantage relative to patients with HPV-negative tumors.
E A Sisk; C R Bradford; A Jacob; C H Yian; K M Staton; G Tang; M O Harris; T E Carey; W D Lancaster; L Gregoire
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Head & neck     Volume:  22     ISSN:  1043-3074     ISO Abbreviation:  Head Neck     Publication Date:  2000 Oct 
Date Detail:
Created Date:  2000-10-27     Completed Date:  2000-11-30     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8902541     Medline TA:  Head Neck     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  649-57     Citation Subset:  IM    
Copyright Information:
Copyright 2000 John Wiley & Sons, Inc.
Department of Otolaryngology/Head and Neck Surgery, The University of Michigan, 1904 Taubman Center, 1500 E. Medical Center Drive, Ann Arbor, Michigan 48109, USA.
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MeSH Terms
Blotting, Southern
Carcinoma, Squamous Cell / genetics,  mortality,  virology*
DNA, Neoplasm / analysis
DNA, Viral / analysis
Head and Neck Neoplasms / genetics,  mortality,  virology*
Middle Aged
Papillomaviridae / genetics*
Papillomavirus Infections / genetics,  mortality,  virology*
Polymerase Chain Reaction
Retrospective Studies
Survival Rate
Tumor Virus Infections / genetics,  mortality,  virology*
Grant Support
Reg. No./Substance:
0/DNA, Neoplasm; 0/DNA, Viral

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