| Human papillomavirus infection in progressive and non-progressive cervical intraepithelial neoplasia. | |
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MedLine Citation:
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PMID: 9048869 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Human papillomavirus (HPV) infection is common in cervical intraepithelial neoplasia (CIN) and is widely held to be responsible for its progression to grade 3. This thesis is examined here. Comparison of the level of HPV changes in 133 lesions that had not progressed to that in those from 197 women with histologically proven CIN 3 failed to reveal significant differences in their level of HPV infection on cytology, histology or in situ hybridization. However, in both these groups, some of the cases that did not show HPV positivity on in situ hybridization with probes reacting with the common HPV types did show evidence of HPV DNA using a general primer-mediated polymerase chain reaction. This may indicate low-copy number infections or non-productive infections. Such reactions were more frequent in the women with progressive lesions, and it is probable that they may also have been at greater risk of cervical infection in general. The present findings suggest that a further factor, a cocarcinogen, may be involved in progression to CIN 3, HPV being a common forerunner, providing a proliferative environment and thus favoring such an event. |
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Authors:
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B Bertelsen; M B Kalvenes; F Hartveit |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: APMIS : acta pathologica, microbiologica, et immunologica Scandinavica Volume: 104 ISSN: 0903-4641 ISO Abbreviation: APMIS Publication Date: 1996 Dec |
Date Detail:
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Created Date: 1997-03-20 Completed Date: 1997-03-20 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8803400 Medline TA: APMIS Country: DENMARK |
Other Details:
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Languages: eng Pagination: 900-6 Citation Subset: IM |
Affiliation:
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Gade Institute, Department of Pathology, University of Bergen, Haukeland Hospital, Norway. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Cell Transformation, Neoplastic Cervical Intraepithelial Neoplasia / pathology, virology* DNA, Viral / analysis Female Humans In Situ Hybridization Papillomaviridae / isolation & purification* Papillomavirus Infections / pathology* Polymerase Chain Reaction Tumor Virus Infections / pathology* Uterine Cervical Neoplasms / pathology, virology* |
| Chemical | |
Reg. No./Substance:
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0/DNA, Viral |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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