Document Detail

Human papillomavirus infection in progressive and non-progressive cervical intraepithelial neoplasia.
MedLine Citation:
PMID:  9048869     Owner:  NLM     Status:  MEDLINE    
Human papillomavirus (HPV) infection is common in cervical intraepithelial neoplasia (CIN) and is widely held to be responsible for its progression to grade 3. This thesis is examined here. Comparison of the level of HPV changes in 133 lesions that had not progressed to that in those from 197 women with histologically proven CIN 3 failed to reveal significant differences in their level of HPV infection on cytology, histology or in situ hybridization. However, in both these groups, some of the cases that did not show HPV positivity on in situ hybridization with probes reacting with the common HPV types did show evidence of HPV DNA using a general primer-mediated polymerase chain reaction. This may indicate low-copy number infections or non-productive infections. Such reactions were more frequent in the women with progressive lesions, and it is probable that they may also have been at greater risk of cervical infection in general. The present findings suggest that a further factor, a cocarcinogen, may be involved in progression to CIN 3, HPV being a common forerunner, providing a proliferative environment and thus favoring such an event.
B Bertelsen; M B Kalvenes; F Hartveit
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  APMIS : acta pathologica, microbiologica, et immunologica Scandinavica     Volume:  104     ISSN:  0903-4641     ISO Abbreviation:  APMIS     Publication Date:  1996 Dec 
Date Detail:
Created Date:  1997-03-20     Completed Date:  1997-03-20     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8803400     Medline TA:  APMIS     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  900-6     Citation Subset:  IM    
Gade Institute, Department of Pathology, University of Bergen, Haukeland Hospital, Norway.
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MeSH Terms
Cell Transformation, Neoplastic
Cervical Intraepithelial Neoplasia / pathology,  virology*
DNA, Viral / analysis
In Situ Hybridization
Papillomaviridae / isolation & purification*
Papillomavirus Infections / pathology*
Polymerase Chain Reaction
Tumor Virus Infections / pathology*
Uterine Cervical Neoplasms / pathology,  virology*
Reg. No./Substance:
0/DNA, Viral

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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