| Human papillomavirus genotypes associated with cervical neoplasia in India. | |
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MedLine Citation:
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PMID: 16884371 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The aim of this study was to determine the prevalence of human papillomavirus (HPV) genotypes in tissue with cervical neoplasias in patients from south and east India. Cross-sectional cervical tissue was obtained from 100 patients from south India and 30 patients from east India who had a biopsy for clinically invasive cervical cancer or cervical intraepithelial neoplasia (CIN) in a tertiary care hospital in India. DNA amplification was done with biotinylated PGMY 09/11 primers, and the line blot assay was used to determine the HPV genotype. HPV DNA was detected in 95% of invasive cancers (113/119) and 91% of CINs (10/11). A single HPV type was found in 100 women (77%), and mixed infections were found in 23 women (18%). HPV 16 (60%) and HPV 18 (14%) were the most frequent types, but 16 other types (26, 31, 33, 35, 42, 45, 51, 52, 53, 56, 58, 61, 62, 64, 81, and 82) were also identified. HPV 16 was present in 63% of patients from south India and in 50% of patients from east India, while HPV 18 was present in 12% and 20%, respectively. There are several high-risk HPV types associated with cervical neoplasias of which types 16 and 18 are the most common. |
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Authors:
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A Peedicayil; P Abraham; N Sathish; S John; K Shah; G Sridharan; P Gravitt |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: International journal of gynecological cancer : official journal of the International Gynecological Cancer Society Volume: 16 ISSN: 1048-891X ISO Abbreviation: Int. J. Gynecol. Cancer Publication Date: 2006 Jul-Aug |
Date Detail:
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Created Date: 2006-08-03 Completed Date: 2006-12-05 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9111626 Medline TA: Int J Gynecol Cancer Country: United States |
Other Details:
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Languages: eng Pagination: 1591-5 Citation Subset: IM |
Affiliation:
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Department of Obstetrics and Gynaecology, Christian Medical College Hospital, Vellore, India. abraham@cmcvellore.ac.in |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Carcinoma, Adenosquamous / epidemiology, virology Carcinoma, Neuroendocrine / epidemiology, virology Carcinoma, Squamous Cell / epidemiology, virology Cervical Intraepithelial Neoplasia / epidemiology, virology DNA, Viral / genetics Female Genotype Human papillomavirus 16 / genetics*, isolation & purification, pathogenicity Human papillomavirus 18 / genetics*, isolation & purification, pathogenicity Humans India / epidemiology Papillomavirus Infections / epidemiology, virology* Polymerase Chain Reaction Uterine Cervical Neoplasms / epidemiology, virology* |
| Chemical | |
Reg. No./Substance:
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0/DNA, Viral |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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