Document Detail

Human papillomavirus and cervical intraepithelial neoplasia in women who subsequently had invasive cancer.
MedLine Citation:
PMID:  2154306     Owner:  NLM     Status:  MEDLINE    
In a retrospective case-control study biopsy specimens of cervical intraepithelial neoplasia (CIN) lesions from 47 women in whom invasive cancer subsequently developed (cases) and from 94 control subjects in whom CIN was diagnosed within 6 months of the diagnosis for the matched case subject but invasive disease did not develop were tested for human papillomavirus (HPV) DNA with tissue in-situ hybridization. There were no significant differences in the frequency of detection of HPV DNA between the two groups. In a cross-sectional survey the prevalence of HPV DNA was found to be 11% in specimens without CIN, 27% in those with CIN I, 49% in those with CIN II and 56% in those with CIN III. The positivity rates for HPV 16/33 DNA increased with the severity of CIN, but this was not observed for HPV 6/11 and 18 DNA. A comparison of the results of the case-control and cross-sectional studies suggested that the younger cohort of women had higher prevalence rates of HPV DNA than the older cohort.
D Caussy; L D Marrett; A J Worth; M McBride; W E Rawls
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne     Volume:  142     ISSN:  0820-3946     ISO Abbreviation:  CMAJ     Publication Date:  1990 Feb 
Date Detail:
Created Date:  1990-03-20     Completed Date:  1990-03-20     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  9711805     Medline TA:  CMAJ     Country:  CANADA    
Other Details:
Languages:  eng     Pagination:  311-7     Citation Subset:  AIM; IM    
Department of Pathology, McMaster University, Hamilton, Ont.
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MeSH Terms
Case-Control Studies
Cross-Sectional Studies
DNA, Viral / analysis*
Middle Aged
Nucleic Acid Hybridization
Papillomaviridae / genetics*
Retrospective Studies
Risk Factors
Uterine Cervical Neoplasms / microbiology*,  pathology
Reg. No./Substance:
0/DNA, Viral

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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