Document Detail

Human papillomavirus-associated tumors of the skin and mucosa.
MedLine Citation:
PMID:  9146528     Owner:  NLM     Status:  MEDLINE    
This review discusses diseases of the lower genital tract in which the presence of human papillomavirus (HPV) DNA is well documented. We discuss epidemiologic, clinical, and experimental data supporting a causative role for HPV in mucosal malignancies, with emphasis on the role of viral and host factors in their pathogenesis. Of special interest is the recently discovered association of cutaneous tumors with HPVs, previously known only for tumors in epidermodysplasia verruciformis (EV). The frequent detection of EV-specific or EV-related HPVs in immunosuppressed persons and in cutaneous tumors in the general population supports the importance of EV as a model of cutaneous oncogenesis. We also discuss recent serologic findings based on enzyme-linked immunosorbent assay results with the use of viruslike particles. This is important both for detection of present or past HPV infection and for epidemiologic and immunologic studies. Novel therapeutic modalities for HPV tumors and prospects for prophylactic and therapeutic vaccination are presented.
S Majewski; S Jablonska
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Journal of the American Academy of Dermatology     Volume:  36     ISSN:  0190-9622     ISO Abbreviation:  J. Am. Acad. Dermatol.     Publication Date:  1997 May 
Date Detail:
Created Date:  1997-06-04     Completed Date:  1997-06-04     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7907132     Medline TA:  J Am Acad Dermatol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  659-85; quiz 686-8     Citation Subset:  IM    
Department of Dermatology, Warsaw School of Medicine, Poland.
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MeSH Terms
Anus Neoplasms / diagnosis,  therapy,  virology*
Epidermodysplasia Verruciformis / complications,  virology
Mucous Membrane
Papillomaviridae* / genetics,  isolation & purification
Papillomavirus Infections* / diagnosis,  therapy,  virology
Penile Neoplasms / diagnosis,  therapy,  virology*
Skin Neoplasms / virology*
Tumor Virus Infections* / diagnosis,  therapy,  virology
Vulvar Neoplasms / diagnosis,  therapy,  virology*

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