| Human papillomavirus, anal squamous intraepithelial lesions, and human immunodeficiency virus in a cohort of gay men. | |
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MedLine Citation:
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PMID: 9652422 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Cross-sectional associations between human papillomavirus (HPV), anal squamous intraepithelial lesions (SIL), and human immunodeficiency virus (HIV) were studied in a cohort of gay men. HPV DNA was detected by generic and type-specific polymerase chain reaction (PCR) probes and hybrid capture assay (HC). HPV virus load was estimated by HC relative light unit (RLU) ratio. HPV prevalence, number of HPV types detected, and HC RLU ratios were each greater in HIV-positive than HIV-negative participants. Further, among HIV-positive men, HC RLU ratio was inversely associated with CD4 cell count. SIL was more frequent in HIV-positive participants, particularly those with a CD4 cell count <200/microL and was positively associated with HPV. Men with a high HC RLU ratio were nearly 3 times more likely to have SIL than were those both PCR- and HC-negative. These data support that HIV augments HPV-associated anal disease in this population. |
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Authors:
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H B Friedman; A J Saah; M E Sherman; A E Busseniers; W C Blackwelder; R A Kaslow; A M Ghaffari; R W Daniel; K V Shah |
Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: The Journal of infectious diseases Volume: 178 ISSN: 0022-1899 ISO Abbreviation: J. Infect. Dis. Publication Date: 1998 Jul |
Date Detail:
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Created Date: 1998-07-27 Completed Date: 1998-07-27 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0413675 Medline TA: J Infect Dis Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 45-52 Citation Subset: AIM; IM; X |
Affiliation:
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Division of Microbiology and Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland, USA. hfriedma@usuhs.mil |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Anus Neoplasms / complications*, epidemiology, pathology, virology CD4 Lymphocyte Count Carcinoma in Situ / complications*, epidemiology, pathology, virology Cohort Studies Cross-Sectional Studies DNA Probes, HPV HIV Infections / complications*, virology Homosexuality, Male* Humans Male Papillomaviridae* / genetics, physiology Papillomavirus Infections / complications, epidemiology, pathology, virology Prevalence Tumor Virus Infections / complications*, epidemiology, pathology, virology Viral Load |
| Grant Support | |
ID/Acronym/Agency:
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AI-35042/AI/NIAID NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/DNA Probes, HPV |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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