Document Detail

Human papillomavirus-16 and -18 replication in esophagus squamous cancer cell lines does not require heterologous E1 and E2 proteins.
MedLine Citation:
PMID:  7666044     Owner:  NLM     Status:  MEDLINE    
Human papillomaviruses (HPVs) are double-stranded DNA viruses that replicate in the nuclei of squamous epithelial cells. HPVs can be classified into high-risk (e.g., types 16, 18, 31, and 33) or low-risk (e.g., types 6, 11, and 30), depending on their association with benign or malignant tumors. We recently described the association of HPV-16 and -18 with esophagus squamous cell cancer. HPV replication was studied in representative cell lines derived from esophagus cancers. HPV-16 and -18 genomes were independently transiently transfected into HCE-4 and HCE-7 cell lines with and without E1 and E2 genes under heterologous promoters. Southern blot analysis demonstrated that these cell lines support viral replication. However, heterologous E1 and E2 are not required for HPV replication. These findings suggest that specific host nuclear factors in esophageal squamous epithelial cells may support HPV replication.
K Togawa; A K Rustgi
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of medical virology     Volume:  45     ISSN:  0146-6615     ISO Abbreviation:  J. Med. Virol.     Publication Date:  1995 Apr 
Date Detail:
Created Date:  1995-10-10     Completed Date:  1995-10-10     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  7705876     Medline TA:  J Med Virol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  435-8     Citation Subset:  IM    
Gastrointestinal Unit, Massachusetts General Hospital, Harvard Medical School, Boston 02114, USA.
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MeSH Terms
Blotting, Southern
Carcinoma, Squamous Cell / virology*
DNA, Viral / analysis
DNA-Binding Proteins*
Esophageal Neoplasms / virology*
Genetic Vectors
Genome, Viral
Oncogene Proteins, Fusion / genetics
Oncogene Proteins, Viral / genetics*
Papillomaviridae / classification,  genetics*,  isolation & purification
Promoter Regions, Genetic
Tumor Cells, Cultured
Virus Replication
Reg. No./Substance:
0/DNA, Viral; 0/DNA-Binding Proteins; 0/E1 protein, Human papillomavirus 16; 0/E2 protein, Human papillomavirus type 16; 0/Oncogene Proteins, Fusion; 0/Oncogene Proteins, Viral; 0/oncogene protein E1, Human papillomavirus type 18; 0/oncogene protein E2, Human papillomavirus type 18

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