Document Detail

Human papilloma virus (HPV) type 16 and 18 detected in head and neck squamous cell carcinoma.
MedLine Citation:
PMID:  9891554     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Recently the HPV genome has been detected in 75-80% of uterine cervical squamous cell carcinomas. High-risk HPV 16,18,31,33, and 45 are frequently associated with invasive carcinoma of the oral cavity, oropharynx, larynx, and nasal cavity. In this study we investigated the association of HPV16 and 18 in head and neck squamous cell carcinomas (HNSCC) using PCR-based methods. MATERIALS AND METHODS: Ninety-eight fresh frozen tissues from HNSCC were collected. The samples were consisted of 26 cases from the larynx, 19 from the nasal and paranasal sinus, 16 the hypopharynx, 14 the oral cavity, 13 the oropharynx, and 10 from the nasopharynx. The presence of HPV genome was examined by PCR using HPV16 and 18 specific primers encoding E7 ORF. RESULTS: HPV16-DNA was detected in 23% of all cases (23/98), 31% (8/26) larynx, 16% (3/19) nasal and paranasal sinus, 19% (3/16) hypopharynx, 21% (3/14) oral cavity, 38% (5/13) oropharynx, and 10% (1/10) nasopharynx. HPV18-DNA was detected in 4% of all cases (4/98), 8% (2/26) larynx, and 15% (2/13) oropharynx. 54% (7/13) in oropharynx and 38% (10/26) in larynx showed rather high prevalence in the head and neck. CONCLUSIONS: HPV 16 and 18 play an important role in carcinogenesis of the head and neck, especially, in the oropharynx and larynx.
H Mineta; T Ogino; H M Amano; Y Ohkawa; K Araki; S Takebayashi; K Miura
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Anticancer research     Volume:  18     ISSN:  0250-7005     ISO Abbreviation:  Anticancer Res.     Publication Date:    1998 Nov-Dec
Date Detail:
Created Date:  1999-01-29     Completed Date:  1999-01-29     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8102988     Medline TA:  Anticancer Res     Country:  GREECE    
Other Details:
Languages:  eng     Pagination:  4765-8     Citation Subset:  IM    
Department of Otolaryngology, Hamamatsu University School of Medicine, Japan.
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MeSH Terms
Carcinoma, Squamous Cell / pathology*,  surgery,  virology*
DNA Primers
Genome, Viral
Head and Neck Neoplasms / pathology*,  surgery,  virology*
Hypopharyngeal Neoplasms / virology
Laryngeal Neoplasms / virology
Mouth Neoplasms / virology
Nasopharyngeal Neoplasms / virology
Neoplasm Invasiveness
Oropharyngeal Neoplasms / virology
Papillomaviridae / genetics,  isolation & purification*
Paranasal Sinus Neoplasms / virology
Polymerase Chain Reaction
Reg. No./Substance:
0/DNA Primers

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