Document Detail

Human "orchestrator" CD11b(+) B1 cells spontaneously secrete interleukin-10 and regulate T-cell activity.
MedLine Citation:
PMID:  22634719     Owner:  NLM     Status:  MEDLINE    
Immune regulation produced by B cells has been attributed to production and secretion of interleukin (IL)-10, which is a characteristic of mouse B1 cells. In view of the widespread clinical use of B-cell depletion therapies in autoimmune and malignant diseases, it is important to monitor the function and fate of regulatory B cells. However, there is no consensus regarding the phenotypic identity of human IL-10(+) B cells. Here we show that human CD11b(+) B1 cells, one of two recently described subpopulations of B1 cells, spontaneously produce IL-10 and suppress T-cell activation. In view of the capacity of these B cells to either stimulate T-cell proliferation or suppress T-cell activation, CD11b(+) B1 cells are considered to be capable of orchestrating elements of immune responsiveness and thus are termed "orchestrator B1 cells," or "B1orc," whereas CD11b(-) B1 cells that primarily secrete antibody are termed "secretor B1 cells," or "B1sec."
Daniel O Griffin; Thomas L Rothstein
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2012-09-07
Journal Detail:
Title:  Molecular medicine (Cambridge, Mass.)     Volume:  18     ISSN:  1528-3658     ISO Abbreviation:  Mol. Med.     Publication Date:  2012  
Date Detail:
Created Date:  2012-09-24     Completed Date:  2013-02-06     Revised Date:  2013-06-24    
Medline Journal Info:
Nlm Unique ID:  9501023     Medline TA:  Mol Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1003-8     Citation Subset:  IM    
Elmezzi Graduate School of Molecular Medicine, The Feinstein Institute for Medical Research, Manhasset, New York 11030, United States of America.
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MeSH Terms
Antigens, CD11b / metabolism*
Antigens, CD24 / metabolism
Antigens, CD27 / metabolism
Antigens, CD38 / metabolism
B-Lymphocytes / secretion*
CD4-Positive T-Lymphocytes / cytology,  immunology
Interleukin-10 / secretion*
Lymphocyte Activation / immunology
Membrane Glycoproteins / metabolism
T-Lymphocytes / cytology,  immunology*
Grant Support
Reg. No./Substance:
0/Antigens, CD11b; 0/Antigens, CD24; 0/Antigens, CD27; 0/CD24 protein, human; 0/IL10 protein, human; 0/ITGAM protein, human; 0/Membrane Glycoproteins; 130068-27-8/Interleukin-10; EC, CD38; EC protein, human

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