| Human ontogeny of the bile duct to portal space ratio. | |
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MedLine Citation:
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PMID: 2737599 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Paucity of interlobular bile ducts is a common feature of cholestatic liver disease in premature infants. Whereas a bile duct to portal space ratio of 0.9 to 1.8 is cited by Alagille as the norm for children, there are no data regarding the normal bile duct to portal space ratio in preterm infants. In this study, by examining liver tissue obtained from autopsied fetuses and infants, we have determined that the bile duct to portal space ratio increases as a function of postconceptional age. After 38 weeks postconception, a ratio equal to or greater than 0.9 was seen in eight of nine subjects. Therefore, in evaluating premature infants for duct paucity, liver biopsies should be obtained only after 38 weeks. Prior to 38 weeks postconception, a bile duct to portal space ratio less than 0.9 may be physiologic. |
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Authors:
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E Kahn; J Markowitz; H Aiges; F Daum |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Hepatology (Baltimore, Md.) Volume: 10 ISSN: 0270-9139 ISO Abbreviation: Hepatology Publication Date: 1989 Jul |
Date Detail:
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Created Date: 1989-07-28 Completed Date: 1989-07-28 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 8302946 Medline TA: Hepatology Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 21-3 Citation Subset: IM |
Affiliation:
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Department of Laboratories, North Shore University Hospital-Cornell University Medical College, Manhasset, New York 11030. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Bile Ducts, Intrahepatic
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anatomy & histology*,
embryology Fetus / anatomy & histology* Gestational Age Humans Infant, Newborn* Liver / anatomy & histology*, embryology |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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