Document Detail


Human ontogeny of the bile duct to portal space ratio.
MedLine Citation:
PMID:  2737599     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Paucity of interlobular bile ducts is a common feature of cholestatic liver disease in premature infants. Whereas a bile duct to portal space ratio of 0.9 to 1.8 is cited by Alagille as the norm for children, there are no data regarding the normal bile duct to portal space ratio in preterm infants. In this study, by examining liver tissue obtained from autopsied fetuses and infants, we have determined that the bile duct to portal space ratio increases as a function of postconceptional age. After 38 weeks postconception, a ratio equal to or greater than 0.9 was seen in eight of nine subjects. Therefore, in evaluating premature infants for duct paucity, liver biopsies should be obtained only after 38 weeks. Prior to 38 weeks postconception, a bile duct to portal space ratio less than 0.9 may be physiologic.
Authors:
E Kahn; J Markowitz; H Aiges; F Daum
Related Documents :
20383819 - Clinical course of obstructive jaundice associated with operated meconium peritonitis i...
24892849 - Micafungin in premature and non-premature infants: a systematic review of nine clinical...
6660629 - Biliary excretion of infused conjugated sulfobromophthalein in sheep heterozygote for t...
24442219 - Clinical course and interstage monitoring after the norwood and hybrid procedures for h...
1491909 - The size and contractility of the gallbladder in infants.
24244099 - Clinical perspectives on esophageal disorders in infants.
1480719 - Myths about aggression and attitudes about the death penalty.
7402789 - Continuous monitoring of arterial oxygen tension in infants: four years of experience w...
15256519 - The association of grandmaternal and maternal factors with maternal adult stature.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Hepatology (Baltimore, Md.)     Volume:  10     ISSN:  0270-9139     ISO Abbreviation:  Hepatology     Publication Date:  1989 Jul 
Date Detail:
Created Date:  1989-07-28     Completed Date:  1989-07-28     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8302946     Medline TA:  Hepatology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  21-3     Citation Subset:  IM    
Affiliation:
Department of Laboratories, North Shore University Hospital-Cornell University Medical College, Manhasset, New York 11030.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Bile Ducts, Intrahepatic / anatomy & histology*,  embryology
Fetus / anatomy & histology*
Gestational Age
Humans
Infant, Newborn*
Liver / anatomy & histology*,  embryology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Similarities in maximal biliary bilirubin output in the normal rat after administration of unconjuga...
Next Document:  Treatment of chronic type B hepatitis with recombinant alpha-interferon induces autoantibodies not s...