| Human nuclear clusterin mediates apoptosis by interacting with Bcl-XL through C-terminal coiled coil domain. | |
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MedLine Citation:
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PMID: 21567405 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Clusterin (CLU), a glycoprotein, is involved in apoptosis, producing two alternatively spliced isoforms in various cell types. The pro-apoptotic CLU appears to be a nuclear isoform (nuclear clusterin; nCLU), and the secretory CLU (sCLU) is thought to be anti-apoptotic. The detailed molecular mechanism of nCLU as a pro-apoptotic molecule has not yet been clear. In the current study, overexpressed nCLU induced apoptosis in human kidney cells. Biochemical studies revealed that nCLU sequestered Bcl-XL via a putative BH3 motif in the C-terminal coiled coil (CC2) domain, releasing Bax, and promoted apoptosis accompanied by activation of caspase-3 and cytochrome c release. These results suggest a novel mechanism of apoptosis mediated by nCLU as a pro-apoptotic molecule. J. Cell. Physiol. © 2011 Wiley-Liss, Inc. |
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Authors:
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Nayoung Kim; Jae Cheal Yoo; Jae Yoon Han; Eun Mi Hwang; Yoon Sook Kim; Eun Young Jeong; Choong-Hyun Sun; Gwan-Su Yi; Gu Seob Roh; Hyun Joon Kim; Sang Soo Kang; Gyeong Jae Cho; Jae Yong Park; Wan Sung Choi |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-5-12 |
Journal Detail:
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Title: Journal of cellular physiology Volume: - ISSN: 1097-4652 ISO Abbreviation: - Publication Date: 2011 May |
Date Detail:
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Created Date: 2011-5-13 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0050222 Medline TA: J Cell Physiol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2011 Wiley-Liss, Inc. |
Affiliation:
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Department of Anatomy and Neurobiology, Medical Research Center for Neural Dysfunction, School of Medicine, Gyeongsang National University, 92 Chilam-dong, Jinju, Gyeongnam 660-751, South Korea. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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