| Human nonvisual responses to simultaneous presentation of blue and red monochromatic light. | |
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MedLine Citation:
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PMID: 22306975 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Blue light sensitivity of melatonin suppression and subjective mood and alertness responses in humans is recognized as being melanopsin based. Observations that long-wavelength (red) light can potentiate responses to subsequent short-wavelength (blue) light have been attributed to the bistable nature of melanopsin whereby it forms stable associations with both 11-cis and all-trans isoforms of retinaldehyde and uses light to transition between these states. The current study examined the effect of concurrent administration of blue and red monochromatic light, as would occur in real-world white light, on acute melatonin suppression and subjective mood and alertness responses in humans. Young healthy men (18-35 years; n = 21) were studied in highly controlled laboratory sessions that included an individually timed 30-min light stimulus of blue (λ(max) 479 nm) or red (λ(max) 627 nm) monochromatic light at varying intensities (10(13)-10(14) photons/cm(2)/sec) presented, either alone or in combination, in a within-subject randomized design. Plasma melatonin levels and subjective mood and alertness were assessed at regular intervals relative to the light stimulus. Subjective alertness levels were elevated after light onset irrespective of light wavelength or irradiance. For melatonin suppression, a significant irradiance response was observed with blue light. Co-administration of red light, at any of the irradiances tested, did not significantly alter the response to blue light alone. Under the current experimental conditions, the primary determinant of the melatonin suppression response was the irradiance of blue 479 nm light, and this was unaffected by simultaneous red light administration. |
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Authors:
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Christiana Papamichael; Debra J Skene; Victoria L Revell |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of biological rhythms Volume: 27 ISSN: 1552-4531 ISO Abbreviation: J. Biol. Rhythms Publication Date: 2012 Feb |
Date Detail:
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Created Date: 2012-02-06 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8700115 Medline TA: J Biol Rhythms Country: United States |
Other Details:
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Languages: eng Pagination: 70-8 Citation Subset: IM |
Affiliation:
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Chronobiology, Faculty of Health and Medical Sciences, University of Surrey, Guildford, Surrey, UK. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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