| Human nevi: no longer precursors of melanomas? | |
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MedLine Citation:
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PMID: 22895446 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Considerable data support the idea that oncogene-induced senescence remains a barrier that needs to be overcome for malignant transformation of melanocytes. Human nevi stain positive for the senescence-associated β-galactosidase marker, suggesting that cells have lost their proliferative capacity. Most nevi harbor B-RAF or N-RAS mutations, implying that they are growth arrested via oncogene-induced senescence pathways. It remains intriguing how benign nevus cells can escape oncogene-induced senescence for malignant transformation to melanoma. The report by Tran et al. in this issue shows that current senescence markers do not distinguish nevi from melanomas, challenging the notion that nevi are growth-arrested via senescence. |
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Authors:
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Gao Zhang; Meenhard Herlyn |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The Journal of investigative dermatology Volume: 132 ISSN: 1523-1747 ISO Abbreviation: J. Invest. Dermatol. Publication Date: 2012 Sep |
Date Detail:
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Created Date: 2012-08-16 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0426720 Medline TA: J Invest Dermatol Country: United States |
Other Details:
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Languages: eng Pagination: 2133-4 Citation Subset: IM |
Affiliation:
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1] Tumor Microenvironment and Metastasis Program, The Wistar Institute, Philadelphia, Pennsylvania, USA [2] Department of Bioengineering, University of Pennsylvania, Philadelphia, Pennsylvania, USA. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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