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Human nevi: no longer precursors of melanomas?
MedLine Citation:
PMID:  22895446     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Considerable data support the idea that oncogene-induced senescence remains a barrier that needs to be overcome for malignant transformation of melanocytes. Human nevi stain positive for the senescence-associated β-galactosidase marker, suggesting that cells have lost their proliferative capacity. Most nevi harbor B-RAF or N-RAS mutations, implying that they are growth arrested via oncogene-induced senescence pathways. It remains intriguing how benign nevus cells can escape oncogene-induced senescence for malignant transformation to melanoma. The report by Tran et al. in this issue shows that current senescence markers do not distinguish nevi from melanomas, challenging the notion that nevi are growth-arrested via senescence.
Authors:
Gao Zhang; Meenhard Herlyn
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of investigative dermatology     Volume:  132     ISSN:  1523-1747     ISO Abbreviation:  J. Invest. Dermatol.     Publication Date:  2012 Sep 
Date Detail:
Created Date:  2012-08-16     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0426720     Medline TA:  J Invest Dermatol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2133-4     Citation Subset:  IM    
Affiliation:
1] Tumor Microenvironment and Metastasis Program, The Wistar Institute, Philadelphia, Pennsylvania, USA [2] Department of Bioengineering, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
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