Document Detail

Human neutrophil lipocalin: normal levels and use as a marker for invasive infection in the newborn.
MedLine Citation:
PMID:  15188983     Owner:  NLM     Status:  MEDLINE    
AIM: To evaluate human neutrophil lipocalin (HNL) as a marker of neonatal invasive infection and determine the normal serum levels of HNL in newborns. METHODS: HNL is released from neutrophil granulocytes and is regarded as a specific marker of neutrophil activity. In 81 newborns < or = 28 d of age with signs of infection on a total of 87 occasions, HNL and C-reactive protein (CRP) were measured at inclusion and on the three following days. As controls, term healthy newborns were recruited at birth (cord blood, n = 45) and at ages 3-5 d (n = 46). Serum HNL was measured by a radioimmunoassay. RESULTS: 25/87 episodes were classified as infection and 62 as non-proven infection. HNLmax was significantly higher in the infected group (mean 587.6 microg/l) than in the non-proven infected group (mean 217.7 microg/, p < 0.001). HNL peaked at inclusion, 1 d earlier than CRP. In the healthy controls. HNL was the same at 3-5 d of age as at birth (mean 82.4-81.7 microg/l) and similar to normal adult levels. CONCLUSIONS: The release of HNL is not increased in healthy newborns at birth, but neonatal neutrophils rapidly release HNL upon microbial stimulation in vivo. HNL might be useful as an early marker of neonatal infection.
M Björkqvist; J Källman; G Fjaertoft; S Xu; P Venge; J Schollin
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Acta paediatrica (Oslo, Norway : 1992)     Volume:  93     ISSN:  0803-5253     ISO Abbreviation:  Acta Paediatr.     Publication Date:  2004 Apr 
Date Detail:
Created Date:  2004-06-10     Completed Date:  2004-09-01     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9205968     Medline TA:  Acta Paediatr     Country:  Norway    
Other Details:
Languages:  eng     Pagination:  534-9     Citation Subset:  IM    
Department of Paediatrics, Orebro University Hospital, Orebro, Sweden.
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MeSH Terms
Acute-Phase Proteins*
Bacteremia / diagnosis*
Biological Markers / blood*
Birth Weight
C-Reactive Protein / analysis
Carrier Proteins / diagnostic use*
Gestational Age
Infant, Newborn
Neutrophils / metabolism*
Oncogene Proteins*
Proto-Oncogene Proteins
Radioimmunoassay / methods
Sensitivity and Specificity
Reg. No./Substance:
0/Acute-Phase Proteins; 0/Biological Markers; 0/Carrier Proteins; 0/LCN2 protein, human; 0/Lipocalins; 0/Oncogene Proteins; 0/Proto-Oncogene Proteins; 9007-41-4/C-Reactive Protein

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