Document Detail

Human neutrophil hydrogen peroxide generation following physical exercise.
MedLine Citation:
PMID:  2127819     Owner:  NLM     Status:  MEDLINE    
The effects of prolonged, submaximal exercise by seven healthy, untrained individuals on the generation of H2O2 by neutrophils was studied. Hydrogen peroxide generation by neutrophils isolated from pre-exercise (control) and post-exercise blood samples was measured 10, 15 and 20 minutes following stimulation with phorbol myristate acetate (PMA). Exercise was associated with a significant elevation in the number of circulating neutrophils and a diminished capacity for neutrophil H2O2 generation following PMA stimulation. Addition of post-exercise plasma to neutrophils isolated from pre-exercise blood caused a small reduction in H2O2 generation, suggesting the presence of an inhibitory factor(s) in the plasma during physical exercise. These results support the concept that exercise may contribute to an attenuation of oxygen-dependent neutrophil killing.
M Macha; M Shlafer; M J Kluger
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of sports medicine and physical fitness     Volume:  30     ISSN:  0022-4707     ISO Abbreviation:  J Sports Med Phys Fitness     Publication Date:  1990 Dec 
Date Detail:
Created Date:  1991-04-29     Completed Date:  1991-04-29     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0376337     Medline TA:  J Sports Med Phys Fitness     Country:  ITALY    
Other Details:
Languages:  eng     Pagination:  412-9     Citation Subset:  IM    
Department of Physiology, University of Michigan Medical School, Ann Arbor.
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MeSH Terms
Acute-Phase Reaction / immunology
Exercise / physiology*
Hydrogen Peroxide / metabolism*
Leukocyte Count
Neutrophils / drug effects,  immunology,  metabolism*
Phorbol Esters / pharmacology
Reg. No./Substance:
0/Phorbol Esters; 7722-84-1/Hydrogen Peroxide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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