Document Detail

Human neutrophil elastase inhibition with a novel cotton-alginate wound dressing formulation.
MedLine Citation:
PMID:  12918024     Owner:  NLM     Status:  MEDLINE    
Occlusion and elasticity were combined in a novel cotton-based alginate dressing containing a nontoxic elastase inhibitor. Cotton gauzes were modified with a textile finishing process for incorporating alginate to yield a dressing material that retains elasticity while enhancing absorption. The algino-cellulose conjugates were formed through citric acid crosslinking of cellulose and alginate. The alginate-citrate finishes were applied to cotton gauzes in various formulations containing citric acid, sodium hypophosphite, and polyethylene glycol. The modified gauzes contain a citrate conjugate of alginate and cellulose that gels upon hydration. The alginate-citrate finishes were combined with the neutrophil elastase inhibitor, oleic acid, to demonstrate the ability of the algino-cellulose fibers to release the inhibitor and neutralize destructively high levels of neutrophil elastase found in nonhealing and burn wounds. Four types of gauzes were examined for the effect of the algino-cellulose finish on cotton gauze absorbency and elasticity. Fourier transform infrared (FTIR) spectroscopy of the film and alginate-citrate finished cotton showed formation of the alginate and citrate cellulose esters. Scanning electron microscopy analysis revealed large areas of the yarn surface covered by the alginate film with a smooth surface on the original fibers. Wetting of the gauze surface resulted in formation of a hydrated gel on the yarns with apparent swelling of the film and the fiber-coated alginate.
J Vincent Edwards; Alvin F Bopp; Sarah L Batiste; Wilton R Goynes
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of biomedical materials research. Part A     Volume:  66     ISSN:  1549-3296     ISO Abbreviation:  -     Publication Date:  2003 Sep 
Date Detail:
Created Date:  2003-08-14     Completed Date:  2004-08-17     Revised Date:  2004-12-15    
Medline Journal Info:
Nlm Unique ID:  101234237     Medline TA:  J Biomed Mater Res A     Country:  United States    
Other Details:
Languages:  eng     Pagination:  433-40     Citation Subset:  IM    
USDA, Agriculture Research Service, Southern Regional Research Center, Cotton Textile Chemistry, 1100 Robert E. Lee Boulevard, New Orleans, Louisiana 70124, USA.
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MeSH Terms
Alginates / administration & dosage*,  chemistry
Carbohydrate Conformation
Cotton Fiber*
Glucuronic Acid / administration & dosage*,  chemistry
Hexuronic Acids / administration & dosage*,  chemistry
Leukocyte Elastase / antagonists & inhibitors*
Microscopy, Electron, Scanning
Molecular Sequence Data
Spectroscopy, Fourier Transform Infrared
Reg. No./Substance:
0/Alginates; 0/Hexuronic Acids; 576-37-4/Glucuronic Acid; 9005-32-7/alginic acid; EC Elastase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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