Document Detail

Human neurophysins--isolation by high performance liquid chromatography from different extracts.
MedLine Citation:
PMID:  6540701     Owner:  NLM     Status:  MEDLINE    
Different extraction methods, incomplete data on their amino acid composition and different designations according to their electrophoretic mobility result in a still somewhat unclear picture of the human neurophysins. In respect to the limited amount of human material we compared the traditional extraction method with extraction procedures after removal of either HGH or of the proopiocortin-peptides. The purification of these extracts by high performance liquid chromatography resulted in an identical pattern of six neurophysin peaks. They all showed the typical characteristics of the neurophysins. According to their amino acid composition they represent two groups of neurophysins. The analysis of the peaks 4--6 is similar to the amino acid composition of neurophysin I; the main compositional characteristics of the peaks 1--3 are those of neurophysin II. However, sequencing work is needed, before the picture in the human neurophysins will be clarified.
W O Richter; P Schwandt
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Experimental and clinical endocrinology     Volume:  83     ISSN:  0232-7384     ISO Abbreviation:  Exp. Clin. Endocrinol.     Publication Date:  1984 May 
Date Detail:
Created Date:  1984-10-10     Completed Date:  1984-10-10     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8302802     Medline TA:  Exp Clin Endocrinol     Country:  GERMANY, EAST    
Other Details:
Languages:  eng     Pagination:  320-6     Citation Subset:  IM    
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MeSH Terms
Amino Acids / analysis
Chromatography, High Pressure Liquid*
Hydrogen-Ion Concentration
Neurophysins / analysis,  isolation & purification*
Reg. No./Substance:
0/Amino Acids; 0/Neurophysins

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