Document Detail

Human neoplastic cells in tissue culture: two established cell lines derived from giant cell tumor and fibrosarcoma.
MedLine Citation:
PMID:  1004657     Owner:  NLM     Status:  MEDLINE    
The establishment and cultivation of two human neoplastic cell lines is described. The cell line B-5GT was derived from bone giant cell tumor and B-6FS from poorly differentiated fibrosarcoma. In comparison to the normal skin fibroblasts both cell lines have a potential for "indefinite" multiplication in vitro and they exhibit growth properties which are associated with malignant transformation. The parameters investigated included cell morphology, chromosome characteristics, terminal cell density, growth pattern, residual DNA synthesis and growth in soft agar. Both cell lines exhibited human karyotype with aneuploidy and differed in their karyotype from each other.
V Thurzo; M Popovic; J Matoska; M Blasko; M Grófová; A Lizonová; M Steno
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Neoplasma     Volume:  23     ISSN:  0028-2685     ISO Abbreviation:  Neoplasma     Publication Date:  1976  
Date Detail:
Created Date:  1977-02-26     Completed Date:  1977-02-26     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0377266     Medline TA:  Neoplasma     Country:  CZECHOSLOVAKIA    
Other Details:
Languages:  eng     Pagination:  577-87     Citation Subset:  IM    
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MeSH Terms
Bone Neoplasms*
Cell Division
Cell Line*
Cell Nucleolus / ultrastructure
Cell Nucleus / ultrastructure
DNA, Neoplasm / biosynthesis
Giant Cell Tumors*
Mitochondria / ultrastructure
Oncogenic Viruses
Preservation, Biological
Reg. No./Substance:
0/DNA, Neoplasm

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