Document Detail

Human neoplasm pH and response to radiation therapy: P-31 MR spectroscopy studies in situ.
MedLine Citation:
PMID:  2916046     Owner:  NLM     Status:  MEDLINE    
Thirty-five human neoplasms from various sites and of various histologic types and stages were examined with phosphorus-31 magnetic resonance spectroscopy in situ. The tumors included 13 squamous cell carcinomas of the head and neck (lymph nodes), eight Hodgkin lymphomas, six non-Hodgkin lymphomas, four carcinomas of the breast, one melanoma, one sarcoma, one neuroblastoma, and one mucoepidermoid sarcoma of the salivary glands. Thirty-four of the neoplasms had normal to slightly alkaline pH before irradiation. During fractionated radiation therapy, the pH stayed in a range of from near neutral to alkaline and rose to 7.6-8.0 at several time points of radiation therapy for some tumors. These results suggest that most tumor cells in human neoplasms are well oxygenated and that only a negligible fraction are chronic hypoxic cells. The fluctuating alkaline pH during radiation therapy occurred regardless of the responsiveness of the treated tumors.
T C Ng; A W Majors; S Vijayakumar; N J Baldwin; F J Thomas; I Koumoundouros; M E Taylor; S F Grundfest; T F Meaney; R R Tubbs
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Radiology     Volume:  170     ISSN:  0033-8419     ISO Abbreviation:  Radiology     Publication Date:  1989 Mar 
Date Detail:
Created Date:  1989-03-23     Completed Date:  1989-03-23     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0401260     Medline TA:  Radiology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  875-8     Citation Subset:  AIM; IM    
MR Research Center, Cleveland Clinic Foundation, OH 44106.
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MeSH Terms
Carcinoma, Squamous Cell / diagnosis*,  radiotherapy
Dose-Response Relationship, Radiation
Hodgkin Disease / diagnosis*,  radiotherapy
Hydrogen-Ion Concentration
Lymphoma, Non-Hodgkin / diagnosis*,  radiotherapy
Magnetic Resonance Imaging
Magnetic Resonance Spectroscopy / diagnostic use*
Radiotherapy Dosage
Grant Support
Comment In:
Radiology. 1989 Nov;173(2):572-4   [PMID:  2610757 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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