Document Detail

Human neocortical and hippocampal near-DC shifts are interconnected.
MedLine Citation:
PMID:  17372976     Owner:  NLM     Status:  MEDLINE    
Hippocampal DC shifts have been observed under various physiological and pathological conditions. Here, we studied the interconnection of slow shifts (0.01 Hz high-pass) in surface EEG and hippocampal shifts as emerging in an event-related EEG biofeedback paradigm. Hippocampal EEG activity was monitored by depth electrodes implanted in four epilepsy patients for presurgical evaluation. Trials were sorted according to the near-DC shifts occurring at the surface position Cz, which was the feedback electrode, into positive, indistinct (i.e., small or biphasic) and negative shifts. We found significant hippocampal near-DC shifts being positively or negatively correlated to the shifts in surface EEG in all four patients. The amplitudes of the hippocampal near-DC shifts were several times larger than the surface shifts. The polarity of the shifts appears to depend on the location of the electrode contacts with respect to the hippocampal subfields. The finding that neocortical and hippocampal near-DC shifts are interconnected may open new perspectives for the prediction and control of mediotemporal lobe seizures.
Juergen Fell; Navah E Fritz; Wieland Burr; Eva Ludowig; Nikolai Axmacher; Christian E Elger; Christoph Helmstaedter
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Hippocampus     Volume:  17     ISSN:  1050-9631     ISO Abbreviation:  Hippocampus     Publication Date:  2007  
Date Detail:
Created Date:  2007-05-21     Completed Date:  2007-08-02     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  9108167     Medline TA:  Hippocampus     Country:  United States    
Other Details:
Languages:  eng     Pagination:  413-9     Citation Subset:  IM    
Copyright Information:
(c) 2007 Wiley-Liss, Inc.
Department of Epileptology, University of Bonn, D-53105 Bonn, Germany.
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MeSH Terms
Acoustic Stimulation
Biofeedback, Psychology*
Epilepsy, Temporal Lobe / pathology
Functional Laterality / physiology
Hippocampus / physiopathology*
Middle Aged
Neocortex / physiopathology*
Photic Stimulation

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