Document Detail


Human myocardial adenosine triphosphatase activities in health and heart failure.
MedLine Citation:
PMID:  2827453     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This study was designed to determine: (1) the myocardial adenosine triphosphatase (ATPase) activities of normal humans and patients with dilated cardiomyopathy and (2) whether ATPase activity is related to age, cause and severity of heart failure, and digitalis therapy. Endomyocardial biopsies were performed in 32 subjects. Results from six were normal. Ventricular failure in the other 26 was idiopathic (n = 15), familial (n = 3), alcohol induced (n = 5), or related to doxorubicin therapy (n = 3). The biopsies were analyzed for total, mitochondrial, Na+-K+, Ca++, and Mg++ ATPase activities. Total and mitochondrial ATPase activities correlated with left ventricular ejection fraction (r = 0.65 and 0.67, respectively; both p = 0.0001). Residual Mg++ ATPase activity correlated weakly with ventricular function as measured by echocardiography (p = 0.05). Na+-K+ ATPase activity was depressed in patients receiving digitalis (p = 0.01). These results suggest that progressive ventricular dysfunction may be associated with a progressive loss of total ATPase, mitochondrial ATPase and, to a lesser extent, Mg++ ATPase activity. Although depressed mitochondrial ATPase activity is not likely to be the primary cause of ventricular dysfunction, it could perpetuate failure by leading to inadequate production of adenosine triphosphate. Further study of ATPase activities may provide additional insight into the pathogenesis of cardiac failure.
Authors:
D V Unverferth; S W Lee; E T Wallick
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  American heart journal     Volume:  115     ISSN:  0002-8703     ISO Abbreviation:  Am. Heart J.     Publication Date:  1988 Jan 
Date Detail:
Created Date:  1988-01-28     Completed Date:  1988-01-28     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0370465     Medline TA:  Am Heart J     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  139-46     Citation Subset:  AIM; IM    
Affiliation:
Department of Medicine, Ohio State University College of Medicine, Columbus 43210.
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MeSH Terms
Descriptor/Qualifier:
Adenosine Triphosphatases / metabolism*
Adult
Age Factors
Aged
Ca(2+) Mg(2+)-ATPase / metabolism
Calcium-Transporting ATPases / metabolism
Cardiomyopathy, Dilated / drug therapy,  enzymology*
Digitalis
Endocardium / enzymology*
Female
Humans
Male
Middle Aged
Mitochondria, Heart / enzymology
Plants, Medicinal
Plants, Toxic
Sodium-Potassium-Exchanging ATPase / metabolism
Grant Support
ID/Acronym/Agency:
R01-HU-22619//PHS HHS
Chemical
Reg. No./Substance:
EC 3.6.1.-/Adenosine Triphosphatases; EC 3.6.1.-/Ca(2+) Mg(2+)-ATPase; EC 3.6.1.8/Calcium-Transporting ATPases; EC 3.6.3.9/Sodium-Potassium-Exchanging ATPase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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