Document Detail

Human myo-inositol monophosphatase 2, rescues the nematode thermotaxis mutant ttx-7 more efficiently than IMPA1: functional and evolutionary considerations of the two mammalian myo-inositol monophosphatase genes.
MedLine Citation:
PMID:  23205734     Owner:  NLM     Status:  Publisher    
Mammals express two myo-inositol monophosphatase (IMPase) genes, IMPA1/Impa1 and IMPA2/Impa2. In this study, we compared the spatial expression patterns of the two IMPase gene transcripts and proteins in mouse tissues. Results indicated discrete expression of the two IMPase genes and their protein products in various organs, including the brain. In Caenorhabditis elegans, loss of the IMPase gene, ttx-7, disrupts cellular polarity in RIA neurons, eliciting abnormal thermotaxis behavior. We performed a rescue experiment in mutant nematodes using mammalian IMPases. Human IMPA2 rescued the abnormal behavioral phenotype in the ttx-7 mutants more efficiently than IMPA1. These results raise a question about the phylogenetic origin of IMPases and the biological roles of mammalian IMPase 2 in mammals. Impa2 knockout mice generated in our laboratory, exhibited neither behavioral abnormalities nor a significant reduction in myo-inositol content in the brain and other examined tissues. Given the ability of human IMPA2 to rescue the ttx-7 mutant, and its genetic association with multiple neuropsychiatric disorders, close scrutiny of IMPA2 function and the evolutionary origin of IMPase genes is warranted. © 2012 International Society for Neurochemistry, J. Neurochem. (2012) 10.1111/jnc.12112.
Tetsuo Ohnishi; Yoshinori Tanizawa; Akiko Watanabe; Takemichi Nakamura; Hisako Ohba; Haruna Hirata; Chizu Kaneda; Yoshimi Iwayama; Takafumi Arimoto; Kazutada Watanabe; Ikue Mori; Takeo Yoshikawa
Related Documents :
25439234 - Reviving an old hiv-1 gene: the hiv-1 antisense protein.
25037214 - Dynamic transcriptome landscape of maize embryo and endosperm development.
23023974 - Molecular characterisation and structural instability of the industrially important com...
25158754 - Effects of the fecl major gene in the lacaune meat sheep population.
22829954 - A novel vector-based method for exclusive overexpression of star-form micrornas.
10607904 - The induction of skeletal muscle hypertrophy by a ski transgene is promoter-dependent.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-12-4
Journal Detail:
Title:  Journal of neurochemistry     Volume:  -     ISSN:  1471-4159     ISO Abbreviation:  J. Neurochem.     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-12-4     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  2985190R     Medline TA:  J Neurochem     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2012 International Society for Neurochemistry, J. Neurochem. (2012) 10.1111/jnc.12112.
Laboratory for Molecular Psychiatry, RIKEN Brain Science Institute, Wako, Japan.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  External Inosculation as a Feature of Revascularization Occurs After Free Transplantation of Murine ...
Next Document:  Longitudinal growth of very low birth weight neonates during first year of life and risk factors for...