Document Detail

Human and murine tumours: changes in cell surface structures coded by the major histocompatibility complex region.
MedLine Citation:
PMID:  6768809     Owner:  NLM     Status:  MEDLINE    
Serological and structural changes of surface markers involved in immune reactions may occur in human and murine tumour systems. Thus nine out of twenty-one human tumour cell lines and SV40-transformed fibroblasts differed from autologous lymphoblastoid cells or fibroblasts in their reactivity with HLA alloantisera. H-2 antigens isolated from the murine tumour cells 6C3HED and TP1422, undergo structural changes. An alien HLA-B7 was detected in sera from two melanoma patients. The serologic activity of H-2 antigens was significantly increased in the serum and ascites fluid of tumour bearing mice. Additionally, human SV40-transformed fibroblasts acquire receptors for monkey red blood cells and the murine lymphosarcoma cells 6C3HED express receptors for sheep red blood cells.
S Ferrone; M A Pellegrino; G N Callahan
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of immunogenetics     Volume:  7     ISSN:  0305-1811     ISO Abbreviation:  J. Immunogenet.     Publication Date:  1980 Feb 
Date Detail:
Created Date:  1980-07-12     Completed Date:  1980-07-12     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0425125     Medline TA:  J Immunogenet     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  71-9     Citation Subset:  IM    
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MeSH Terms
Cell Line
Cell Membrane / immunology
Fibroblasts / immunology
Genetic Code*
H-2 Antigens
Lymphoma / immunology
Major Histocompatibility Complex*
Melanoma / immunology
Rosette Formation
Staphylococcal Protein A / immunology
beta-Aminoethyl Isothiourea / pharmacology
Reg. No./Substance:
0/H-2 Antigens; 0/Staphylococcal Protein A; 151-16-6/beta-Aminoethyl Isothiourea

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