| Human mucosal leishmaniasis: neutrophils infiltrate areas of tissue damage that express high levels of Th17-related cytokines. | |
| | |
MedLine Citation:
|
PMID: 20812234 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Mucosal leishmaniasis (ML) is characterised by severe tissue destruction. Herein, we evaluated the involvement of the IL-17-type response in the inflammatory infiltrate of biopsy specimens from 17 ML patients. IL-17 and IL-17-inducing cytokines (IL-1β, IL-23, IL-6 and TGF-β) were detected by immunohistochemistry in ML patients. IL-17(+) cells exhibited CD4(+), CD8(+) or CD14(+) phenotypes, and numerous IL-17(+) cells co-expressed the CC chemokine receptor 6 (CCR6). Neutrophils, a hallmark of Th17-mediated inflammation, were regularly detected in necrotic and perinecrotic areas and stained positive for neutrophil elastase, myeloperoxidase and MMP-9. Taken together, these observations demonstrate the existence of Th17 cells in ML lesions associated with neutrophils in areas of tissue injury and suggest that IL-17 is involved in ML pathogenesis. |
| | |
Authors:
|
Viviane S Boaventura; Claire S Santos; Cristina R Cardoso; José de Andrade; Washington L C Dos Santos; Jorge Clarêncio; João S Silva; Valeria M Borges; Manoel Barral-Netto; Claudia I Brodskyn; Aldina Barral |
Related Documents
:
|
7959884 - Priming of the oxidative burst in human neutrophils by physiological agonists or cytoch... 16227824 - Cellular events in the normal and inflamed cornea. 20174624 - Neutrophils are resistant to yersinia yopj/p-induced apoptosis and are protected from r... 8968294 - Role of macrophages in pulmonary late-phase reaction in guinea pigs. 9498714 - Induction of apoptosis by chlorodeoxyadenosine and dexamethasone in b-chronic lymphocyt... 9233644 - Differential effects of the t helper cell type 2-derived cytokines il-4 and il-5 on lig... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: European journal of immunology Volume: 40 ISSN: 1521-4141 ISO Abbreviation: Eur. J. Immunol. Publication Date: 2010 Oct |
Date Detail:
|
Created Date: 2010-11-01 Completed Date: 2010-12-16 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 1273201 Medline TA: Eur J Immunol Country: Germany |
Other Details:
|
Languages: eng Pagination: 2830-6 Citation Subset: IM |
Affiliation:
|
Centro de Pesquisas Gonçalo Moniz, Fundação Oswaldo Cruz, Salvador, Brazil. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals CD4-Positive T-Lymphocytes / immunology CD8-Positive T-Lymphocytes / immunology Female Humans Immunohistochemistry Interleukin-17 / biosynthesis, immunology* Leishmania / immunology* Leishmaniasis, Mucocutaneous / immunology*, parasitology Male Matrix Metalloproteinase 9 / blood, immunology Microscopy, Confocal Middle Aged Neutrophils / enzymology, immunology* Nuclear Receptor Subfamily 1, Group F, Member 3 / immunology Peroxidase / blood, immunology Receptors, CCR6 / immunology* Statistics, Nonparametric |
| Chemical | |
Reg. No./Substance:
|
0/CCR6 protein, human; 0/Interleukin-17; 0/Nuclear Receptor Subfamily 1, Group F, Member 3; 0/Receptors, CCR6; EC 1.11.1.7/Peroxidase; EC 3.4.24.-/Mmp9 protein, mouse; EC 3.4.24.35/Matrix Metalloproteinase 9 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Intraoperative assessment of sentinel lymph nodes in breast cancer.
Next Document: Chitin induces upregulation of B7-H1 on macrophages and inhibits T-cell proliferation.