| Human and mouse macrophage-inducible C-type lectin (Mincle) bind Candida albicans. | |
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MedLine Citation:
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PMID: 18509109 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Candida albicans is a causative agent in mycoses of the skin, oral cavity, and gastrointestinal tract. Identification of receptors, and their respective ligands, that are engaged by immune cells when in contact with C. albicans is crucial for understanding inflammatory responses leading to invasive candidiasis. Mincle is a recently identified macrophage-expressed receptor that is important for host responses to C. albicans. The carbohydrate-recognition domain of human and mouse Mincle were expressed, purified under denaturing conditions, and successfully refolded. In addition to oligomers, there are isolatable monomeric and dimeric forms of the protein that occur under two different buffer solutions. The human and mouse homologues bound yeast extract, and the isolated dimeric and monomeric species also demonstrated the recognition of whole C. albicans yeast cells. The data are indicative of several functional states mediating the interaction of Mincle and yeast at the surface of the macrophage. |
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Authors:
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Andrea Bugarcic; Kelly Hitchens; Anthony G Beckhouse; Christine A Wells; Robert B Ashman; Helen Blanchard |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2008-05-28 |
Journal Detail:
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Title: Glycobiology Volume: 18 ISSN: 1460-2423 ISO Abbreviation: Glycobiology Publication Date: 2008 Sep |
Date Detail:
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Created Date: 2008-08-19 Completed Date: 2008-11-24 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9104124 Medline TA: Glycobiology Country: England |
Other Details:
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Languages: eng Pagination: 679-85 Citation Subset: IM |
Affiliation:
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Institute for Glycomics, Griffith University, Gold Coast Campus, QLD 4222, Australia. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Candida albicans / metabolism* Cell Extracts / pharmacology Cells, Cultured Dimerization Humans Lectins, C-Type / metabolism*, physiology Macrophages / metabolism Male Membrane Proteins / metabolism*, physiology Mice Protein Binding Solubility |
| Chemical | |
Reg. No./Substance:
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0/Cell Extracts; 0/Clecsf8 protein, mouse; 0/Lectins, C-Type; 0/Membrane Proteins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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