Document Detail

Human monocytopoiesis in acute and chronic inflammation.
MedLine Citation:
PMID:  812318     Owner:  NLM     Status:  MEDLINE    
Monocytopoiesis was analyzed in patients with severe, acute inflammations induced by surgical interventions as well as in others with mild, chronic inflammations in connection with gastric or duodenal ulcers. The state of acute inflammation was assumed to be associated with a high and steeply rising monocyte demand as opposed to the constant and relatively small monocyte recruitment in chronic inflammation. In chronic mild inflammatory reactions DNA synthesis activity of promonocytes was increased by a factor of about two; the promonocyte pool was normal. In patients who underwent surgical operations changes in the following parameters were observed during the first 15 h after start of surgery: (1) average increase in 3H-TDR labelling index by 38%; (2) average enlargement of promonocyte pool by 34%, (3) and relase of immature cells from the bone marrow into the blood. Increase in DNA synthesis activity as well as expansion of the promonocyte pool causes an enhanced monocyte production rate. The 'shift to the left' in monocyte egress is equivalent to a reduced stem-cell-to-blood transit time. These variations permit short-term adaptation of monocytopoiesis to varying demands.
G Meuret; U Detel; H P Kilz; H J Senn; H van Lessen
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta haematologica     Volume:  54     ISSN:  0001-5792     ISO Abbreviation:  Acta Haematol.     Publication Date:  1975  
Date Detail:
Created Date:  1976-03-01     Completed Date:  1976-03-01     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0141053     Medline TA:  Acta Haematol     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  328-35     Citation Subset:  IM    
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MeSH Terms
Acute Disease
Cell Nucleus / ultrastructure
Chronic Disease
DNA / biosynthesis
Duodenal Ulcer / blood,  surgery
Inflammation / blood*,  etiology
Leukocyte Count
Middle Aged
Monocytes* / metabolism,  ultrastructure
Postoperative Complications
Stomach Ulcer / blood,  surgery
Reg. No./Substance:

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