| Human monocytic ehrlichiosis. | |
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MedLine Citation:
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PMID: 15536115 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A 56-year-old man with a history of Wegener granulomatosis presented with 6 days of sinus congestion, fever, malaise, myalgias, episcleritis, and a morbilliform rash. An exacerbation of Wegener granulomatosis was the principal concern because of the frequency of flares in that disease. The patient developed acute renal failure, thrombocytopenia, transaminitis, and, finally, severe myocarditis that led to congestive heart failure. Additional history-taking and the evolution of his clinical features led to empirical treatment with doxycycline for human monocytic ehrlichiosis (HME). The diagnosis of HME was confirmed by both a polymerase chain reaction assay for Ehrlichia chaffeensis and by the demonstration of morulae within peripheral blood mononuclear cells. The patient improved promptly following institution of doxycycline, and his cardiac function returned to normal over a period of 4 months. |
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Authors:
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John H Stone; Kerry Dierberg; Ghazaleh Aram; J Stephen Dumler |
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Publication Detail:
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Type: Case Reports; Clinical Conference; Journal Article |
Journal Detail:
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Title: JAMA : the journal of the American Medical Association Volume: 292 ISSN: 1538-3598 ISO Abbreviation: JAMA Publication Date: 2004 Nov |
Date Detail:
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Created Date: 2004-11-10 Completed Date: 2004-11-15 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7501160 Medline TA: JAMA Country: United States |
Other Details:
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Languages: eng Pagination: 2263-70 Citation Subset: AIM; IM |
Affiliation:
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Johns Hopkins Vasculitis Center, Division of Rheumatology, Johns Hopkins Bayview Medical Center, Baltimore, Md 21224, USA. jstone@jhmi.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Anti-Bacterial Agents
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therapeutic use Diagnosis, Differential Doxycycline / therapeutic use Ehrlichia chaffeensis / isolation & purification* Ehrlichiosis* / complications, diagnosis, drug therapy, epidemiology Heart Failure / etiology Humans Male Middle Aged Monocytes / microbiology Polymerase Chain Reaction Wegener Granulomatosis / complications |
| Chemical | |
Reg. No./Substance:
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0/Anti-Bacterial Agents; 564-25-0/Doxycycline |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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