| Human and monkey fetal brain development of the supramammillary-hippocampal projections: a system involved in the regulation of theta activity. | |
| | |
MedLine Citation:
|
PMID: 11135232 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The supramammillary (SUM)-hippocampal pathway plays a central role in the regulation of theta rhythm frequency. We followed its prenatal development in eight Cynomolgus monkeys (Macaca fascicularis) from embryonic day E88 to postnatal day 12 (term 165 days) and in eight human fetuses from 17.5 to 40 gestational weeks, relying on neurochemical criteria established in the adult (Nitsch and Leranth [1993] Neuroscience 55:797-812). We found that 1) SUM afferents reached the dentate juxtagranular and CA2 pyramidal cell layers at midgestation in human fetuses, earlier than in monkeys (two-thirds of gestation [E109]). They co-expressed calretinin, substance P, and acetylcholinesterase but not gamma-aminobutyric acid (GABA) or glutamic acid decarboxylase (GAD); 2) the presumed parent neurons in the monkey SUM expressed calretinin or both calretinin and substance P; 3) most of them were surrounded by GAD-containing terminals that might correspond to the septo-SUM feedback pathway (Leranth et al. [1999] Neuroscience 88:701); and 4) in addition, a large band of calretinin-labeled terminals that did not co-express substance P, GAD, or acetylcholinesterase was present in the deepest one-third of the dentate molecular layer in both the Cynomolgus monkey and human fetuses. It persisted in the adult monkey but not in adult human hippocampus; it remains questionable whether it originates in the SUM. In conclusion, the early ingrowth of the excitatory SUM-hippocampal system in human and non-human primates may contribute to the prenatal activity-dependent development of the hippocampal formation. The possibility and the functional importance of an in utero generation of hippocampal theta-like activity should also be considered. |
| | |
Authors:
|
B Berger; M Esclapez; C Alvarez; G Meyer; M Catala |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: The Journal of comparative neurology Volume: 429 ISSN: 0021-9967 ISO Abbreviation: J. Comp. Neurol. Publication Date: 2001 Jan |
Date Detail:
|
Created Date: 2001-02-22 Completed Date: 2001-03-01 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 0406041 Medline TA: J Comp Neurol Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 515-29 Citation Subset: IM |
Affiliation:
|
INSERM U106, Hôpital Salpêtrière, 75651 Paris cedex 13, France. bberger@infobiogen.fr |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Afferent Pathways
/
embryology,
growth & development Animals Embryonic and Fetal Development Hippocampus / embryology*, growth & development Humans Macaca fascicularis / embryology* Presynaptic Terminals / physiology* Species Specificity Theta Rhythm |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: The percutaneous needle biopsy is safe and recommended in the diagnosis of musculoskeletal masses.
Next Document: Müller cell differentiation in the zebrafish neural retina: evidence of distinct early and late sta...