Document Detail


Human minisatellite loci composed of interspersed GGA-GGT triplet repeats.
MedLine Citation:
PMID:  8587876     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We have isolated two tandemly repeated loci from human DNA which contain long blocks of GGA and GGT trinucleotide repeats. These two repeat unit types, together with other less common variants, are apparently irregularly interspersed along each repeat array. Genotyping methods have been developed for these highly polymorphic loci, including typing by polymerase chain reaction followed by Southern blot hybridization. Linkage analysis in Centre d'Etude du Polymorphisme Humain (CEPH) pedigrees has been used to map the loci to chromosomes 15 and 22. In normal individuals, alleles at these loci can contain thousands of repeats, greatly exceeding repeat copy number at most trinucleotide and other simple repeat loci. No evidence for longer, higher-order repeats was observed among the limited number of repeats sequenced. These loci may represent a transitional state between simple repeat loci and some minisatellites.
Authors:
J A Armour; M Crosier; S Malcolm; J C Chan; A J Jeffreys
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Proceedings. Biological sciences / The Royal Society     Volume:  261     ISSN:  0962-8452     ISO Abbreviation:  Proc. Biol. Sci.     Publication Date:  1995 Sep 
Date Detail:
Created Date:  1996-03-25     Completed Date:  1996-03-25     Revised Date:  2009-09-29    
Medline Journal Info:
Nlm Unique ID:  101245157     Medline TA:  Proc Biol Sci     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  345-9     Citation Subset:  IM    
Affiliation:
Department of Genetics, University of Leicester, U.K.
Data Bank Information
Bank Name/Acc. No.:
GENBANK/X79555;  X79556;  X79557;  X79558
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MeSH Terms
Descriptor/Qualifier:
Animals
Base Sequence
Blotting, Southern
Cloning, Molecular
DNA Primers
DNA Transposable Elements
DNA, Satellite / analysis,  genetics*
Genotype
Hominidae / genetics*
Humans
Molecular Sequence Data
Polymerase Chain Reaction
Repetitive Sequences, Nucleic Acid*
Grant Support
ID/Acronym/Agency:
//Wellcome Trust
Chemical
Reg. No./Substance:
0/DNA Primers; 0/DNA Transposable Elements; 0/DNA, Satellite

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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