Document Detail


Human milk intake and retinopathy of prematurity in extremely low birth weight infants.
MedLine Citation:
PMID:  17606555     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVES: Our goal was to analyze the association between human milk intake and severe retinopathy of prematurity in extremely low birth weight infants. PATIENTS AND METHODS: This study is a secondary analysis of data collected for a trial of glutamine supplementation in extremely low birth weight infants (birth weight <1000 g). Among the 1433 participants in that trial, data are available regarding human milk intake and the occurrence of severe retinopathy of prematurity (defined in this study as retinopathy of prematurity treated surgically) for 1057 infants. The volume of human milk intake was expressed as the mean volume (milliliters per kilogram per day) and the mean proportional volume (proportion of total nutritional intake) from birth to discharge or transfer. Using logistic regression, we estimated odds ratios and 95% confidence intervals for any human milk intake and, among infants who received human milk, for each 10 mL/kg per day and each 10% increase in volume. RESULTS: Of the 1057 infants included in this cohort, 788 infants (75%) received at least some human milk. Among these milk-fed infants, the median volume of human milk intake was 30 mL/kg per day (interquartile range: 6-83 mL/kg per day), and the median proportional volume of human milk intake was 0.18 (interquartile range: 0.03-0.66). One hundred sixty-three infants (15%) developed severe retinopathy of prematurity. CONCLUSIONS: In extremely low birth weight infants, human milk intake was not associated with a decreased risk of severe retinopathy of prematurity.
Authors:
Cherrie D Heller; Michael O'Shea; Qing Yao; John Langer; Richard A Ehrenkranz; Dale L Phelps; W Kenneth Poole; Barbara Stoll; Shahnaz Duara; William Oh; James Lemons; Brenda Poindexter;
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Publication Detail:
Type:  Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Pediatrics     Volume:  120     ISSN:  1098-4275     ISO Abbreviation:  Pediatrics     Publication Date:  2007 Jul 
Date Detail:
Created Date:  2007-07-03     Completed Date:  2007-08-03     Revised Date:  2008-09-16    
Medline Journal Info:
Nlm Unique ID:  0376422     Medline TA:  Pediatrics     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1-9     Citation Subset:  AIM; IM    
Affiliation:
Department of Pediatrics, Wake Forest University School of Medicine, Medical Center Boulevard, Winston-Salem, NC 27157, USA. cheller@wfubmc.edu
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MeSH Terms
Descriptor/Qualifier:
Breast Feeding
Female
Glutamine / administration & dosage
Humans
Infant, Extremely Low Birth Weight*
Infant, Newborn
Male
Milk, Human* / chemistry
Retinopathy of Prematurity / prevention & control*,  surgery
Grant Support
ID/Acronym/Agency:
M01 RR 00070/RR/NCRR NIH HHS; M01 RR 00750/RR/NCRR NIH HHS; M01 RR 06022/RR/NCRR NIH HHS; M01 RR 08084/RR/NCRR NIH HHS; M01 RR00997/RR/NCRR NIH HHS; U01 HD36790/HD/NICHD NIH HHS; U10 HD21364/HD/NICHD NIH HHS; U10 HD21373/HD/NICHD NIH HHS; U10 HD21385/HD/NICHD NIH HHS; U10 HD21397/HD/NICHD NIH HHS; U10 HD21415/HD/NICHD NIH HHS; U10 HD27851/HD/NICHD NIH HHS; U10 HD27853/HD/NICHD NIH HHS; U10 HD27856/HD/NICHD NIH HHS; U10 HD27871/HD/NICHD NIH HHS; U10 HD27880/HD/NICHD NIH HHS; U10 HD27881/HD/NICHD NIH HHS; U10 HD27904/HD/NICHD NIH HHS; U10 HD34216/HD/NICHD NIH HHS; U10 HD40461/HD/NICHD NIH HHS; U10 HD40689/HD/NICHD NIH HHS
Chemical
Reg. No./Substance:
56-85-9/Glutamine
Comments/Corrections
Comment In:
Pediatrics. 2008 Sep;122(3):686-7; author reply 687-8   [PMID:  18762549 ]

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