Document Detail

Human milk fatty acids from lactating mothers of preterm infants: a study revealing wide intra- and inter-individual variation.
MedLine Citation:
PMID:  20417081     Owner:  NLM     Status:  MEDLINE    
Docosahexaenoic acid (DHA) and arachidonic acid (AA) are important nutrients in the preterm diet and fixed ratios have been proposed for formula. We evaluated the intra- and inter-individual variation in milk fatty acids from mothers of preterm infants involved in a randomised trial of tuna oil or placebo supplementation. Milk samples were collected every 2 weeks while infants were hospitalised and fatty acids analysed by capillary gas chromatography. DHA was higher in milk of supplemented mothers than control (% total fatty acids, mean+/-SD, treatment 0.9+/-0.4, control 0.3+/-0.1, p<0.0005) and ranged between 0.3-2.5% and 0.1-1.1%, respectively. AA did not differ between groups and ranged between 0.2-0.9% and 0.3-0.9%, respectively. Control mothers milk had wider AA:DHA ratio than treatment mothers (0.4-3.2 versus 0.2-2.1). Due to the wide variation in milk AA and DHA, statements recommending infant formula based on a fixed AA:DHA ratio should be re-examined.
L G Smithers; M Markrides; R A Gibson
Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't     Date:  2010-04-22
Journal Detail:
Title:  Prostaglandins, leukotrienes, and essential fatty acids     Volume:  83     ISSN:  1532-2823     ISO Abbreviation:  Prostaglandins Leukot. Essent. Fatty Acids     Publication Date:  2010 Jul 
Date Detail:
Created Date:  2010-06-14     Completed Date:  2010-09-10     Revised Date:  2010-10-19    
Medline Journal Info:
Nlm Unique ID:  8802730     Medline TA:  Prostaglandins Leukot Essent Fatty Acids     Country:  Scotland    
Other Details:
Languages:  eng     Pagination:  9-13     Citation Subset:  IM    
Copyright Information:
Copyright 2010 Elsevier Ltd. All rights reserved.
Women's and Children's Health Research Institute, at the Children, Youth and Women's Health Service, North Adelaide and the Flinders Medical Centre, Bedford Park, Australia.
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MeSH Terms
Arachidonic Acid / metabolism*
Docosahexaenoic Acids / administration & dosage*,  metabolism*
Lactation / metabolism*
Milk, Human / metabolism*
Premature Birth / metabolism*
Reg. No./Substance:
25167-62-8/Docosahexaenoic Acids; 506-32-1/Arachidonic Acid

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