Document Detail


Human milk fatty acids from lactating mothers of preterm infants: a study revealing wide intra- and inter-individual variation.
MedLine Citation:
PMID:  20417081     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Docosahexaenoic acid (DHA) and arachidonic acid (AA) are important nutrients in the preterm diet and fixed ratios have been proposed for formula. We evaluated the intra- and inter-individual variation in milk fatty acids from mothers of preterm infants involved in a randomised trial of tuna oil or placebo supplementation. Milk samples were collected every 2 weeks while infants were hospitalised and fatty acids analysed by capillary gas chromatography. DHA was higher in milk of supplemented mothers than control (% total fatty acids, mean+/-SD, treatment 0.9+/-0.4, control 0.3+/-0.1, p<0.0005) and ranged between 0.3-2.5% and 0.1-1.1%, respectively. AA did not differ between groups and ranged between 0.2-0.9% and 0.3-0.9%, respectively. Control mothers milk had wider AA:DHA ratio than treatment mothers (0.4-3.2 versus 0.2-2.1). Due to the wide variation in milk AA and DHA, statements recommending infant formula based on a fixed AA:DHA ratio should be re-examined.
Authors:
L G Smithers; M Markrides; R A Gibson
Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't     Date:  2010-04-22
Journal Detail:
Title:  Prostaglandins, leukotrienes, and essential fatty acids     Volume:  83     ISSN:  1532-2823     ISO Abbreviation:  Prostaglandins Leukot. Essent. Fatty Acids     Publication Date:  2010 Jul 
Date Detail:
Created Date:  2010-06-14     Completed Date:  2010-09-10     Revised Date:  2010-10-19    
Medline Journal Info:
Nlm Unique ID:  8802730     Medline TA:  Prostaglandins Leukot Essent Fatty Acids     Country:  Scotland    
Other Details:
Languages:  eng     Pagination:  9-13     Citation Subset:  IM    
Copyright Information:
Copyright 2010 Elsevier Ltd. All rights reserved.
Affiliation:
Women's and Children's Health Research Institute, at the Children, Youth and Women's Health Service, North Adelaide and the Flinders Medical Centre, Bedford Park, Australia.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Arachidonic Acid / metabolism*
Docosahexaenoic Acids / administration & dosage*,  metabolism*
Female
Humans
Infant
Lactation / metabolism*
Milk, Human / metabolism*
Pregnancy
Premature Birth / metabolism*
Tuna
Chemical
Reg. No./Substance:
25167-62-8/Docosahexaenoic Acids; 506-32-1/Arachidonic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Hydrodynamic stability in posthatchling loggerhead (Caretta caretta) and green (Chelonia mydas) sea ...
Next Document:  Predictors of mortality in COPD.