| Human milk fatty acids from lactating mothers of preterm infants: a study revealing wide intra- and inter-individual variation. | |
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MedLine Citation:
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PMID: 20417081 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Docosahexaenoic acid (DHA) and arachidonic acid (AA) are important nutrients in the preterm diet and fixed ratios have been proposed for formula. We evaluated the intra- and inter-individual variation in milk fatty acids from mothers of preterm infants involved in a randomised trial of tuna oil or placebo supplementation. Milk samples were collected every 2 weeks while infants were hospitalised and fatty acids analysed by capillary gas chromatography. DHA was higher in milk of supplemented mothers than control (% total fatty acids, mean+/-SD, treatment 0.9+/-0.4, control 0.3+/-0.1, p<0.0005) and ranged between 0.3-2.5% and 0.1-1.1%, respectively. AA did not differ between groups and ranged between 0.2-0.9% and 0.3-0.9%, respectively. Control mothers milk had wider AA:DHA ratio than treatment mothers (0.4-3.2 versus 0.2-2.1). Due to the wide variation in milk AA and DHA, statements recommending infant formula based on a fixed AA:DHA ratio should be re-examined. |
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Authors:
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L G Smithers; M Markrides; R A Gibson |
Publication Detail:
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Type: Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't Date: 2010-04-22 |
Journal Detail:
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Title: Prostaglandins, leukotrienes, and essential fatty acids Volume: 83 ISSN: 1532-2823 ISO Abbreviation: Prostaglandins Leukot. Essent. Fatty Acids Publication Date: 2010 Jul |
Date Detail:
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Created Date: 2010-06-14 Completed Date: 2010-09-10 Revised Date: 2010-10-19 |
Medline Journal Info:
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Nlm Unique ID: 8802730 Medline TA: Prostaglandins Leukot Essent Fatty Acids Country: Scotland |
Other Details:
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Languages: eng Pagination: 9-13 Citation Subset: IM |
Copyright Information:
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Copyright 2010 Elsevier Ltd. All rights reserved. |
Affiliation:
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Women's and Children's Health Research Institute, at the Children, Youth and Women's Health Service, North Adelaide and the Flinders Medical Centre, Bedford Park, Australia. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Arachidonic Acid / metabolism* Docosahexaenoic Acids / administration & dosage*, metabolism* Female Humans Infant Lactation / metabolism* Milk, Human / metabolism* Pregnancy Premature Birth / metabolism* Tuna |
| Chemical | |
Reg. No./Substance:
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25167-62-8/Docosahexaenoic Acids; 506-32-1/Arachidonic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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