Document Detail

Human milk and clinical outcomes in VLBW infants: how compelling is the evidence of benefit?
MedLine Citation:
PMID:  17462492     Owner:  NLM     Status:  MEDLINE    
Significant benefits to infant host defense, sensory-neural development, gastrointestinal maturation, and some aspects of nutritional status are observed when premature infants are fed their mothers' own milk. A reduction in infection-related morbidity in human milk-fed premature infants has been reported in nearly a dozen descriptive, and a few quasi-randomized, studies in the past 25 years. Studies on neurodevelopmental outcomes have reported significantly positive effects for human milk intake on mental and motor development, intelligence quotient, and visual acuity compared with the feeding of formula. Human milk-fed infants also have decreased rates of re-hospitalization after discharge. It is unclear how much human milk is needed to provide protection or at what postnatal age the protective effects maximize. More data are warranted to elucidate these questions. Despite the significant benefits of mothers' own milk, nutritional adequacy may be a limiting factor in the infant weighing less than 1500 g at birth. The overall nutritional needs of these infants can be supported with a nutrient supplement, or fortifier, added to the milk.
Yesenia Morales; Richard J Schanler
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Seminars in perinatology     Volume:  31     ISSN:  0146-0005     ISO Abbreviation:  Semin. Perinatol.     Publication Date:  2007 Apr 
Date Detail:
Created Date:  2007-04-27     Completed Date:  2007-06-25     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  7801132     Medline TA:  Semin Perinatol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  83-8     Citation Subset:  IM    
Division of Neonatal-Perinatal Medicine, Schneider Children's Hospital, North Shore-Long Island Jewish Health System, Manhasset, NY 11030, USA.
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MeSH Terms
Cognition / physiology
Food, Fortified*
Infant Nutritional Physiological Phenomena / physiology*
Infant, Newborn
Infant, Very Low Birth Weight / growth & development*
Milk, Human* / immunology,  microbiology
Nutritional Requirements*
Treatment Outcome

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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