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Human metapneumovirus viral load is an important risk factor for disease severity in young children.
MedLine Citation:
PMID:  24686044     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
BACKGROUND: The role of viral load in human metapneumovirus (HMPV) disease severity has not yet been clearly determined.
OBJECTIVE: We evaluated the importance of viral load along with other factors in HMPV disease severity among children aged <3 years old.
STUDY DESIGN: HMPV-positive cases were selected from a cohort of outpatients and hospitalized children with lower respiratory tract infections. HMPV groups (A or B) and viral loads were determined in their nasopharyngeal aspirates. Disease severity was defined by assessing risk for hospitalization and by using two validated clinical severity scores.
RESULTS: Of the 118 HMPV cases detected over 4 years for which viral load could be determined, 60 belonged to genotype A and 58 to genotype B. Baseline characteristics were similar in HMPV-A and HMPV-B mono-infected patients. In multivariate analysis, HMPV hospitalization was associated with viral load ≥1000copies/10(4)cells (OR, 3.2; 95%CI, 1.4-7.4), age <6 months (OR, 3.1; 95%CI, 1.2-8.6) and presence of ≥3 children in the household (OR, 2.7; 95%CI, 1.04-6.9). A high HMPV viral load was also associated with pulmonary rales (p=.03), use of bronchodilators (p=.02) and inhaled corticosteroids (p=.01).
CONCLUSION: HMPV viral load is associated with disease severity in young children along with young age and household crowding.
Authors:
Jean-François Roussy; Julie Carbonneau; Manale Ouakki; Jesse Papenburg; Marie-Ève Hamelin; Gaston De Serres; Guy Boivin
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-3-12
Journal Detail:
Title:  Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology     Volume:  -     ISSN:  1873-5967     ISO Abbreviation:  J. Clin. Virol.     Publication Date:  2014 Mar 
Date Detail:
Created Date:  2014-4-1     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9815671     Medline TA:  J Clin Virol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2014 Elsevier B.V. All rights reserved.
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