Document Detail


Human metapneumovirus keeps dendritic cells from priming antigen-specific naive T cells.
MedLine Citation:
PMID:  23374037     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Human metapneumovirus (hMPV) is the second most common cause of acute lower respiratory tract infections in children, causing a significant public health burden worldwide. Given that hMPV can repeatedly infect the host without major antigenic changes, it has been suggested that hMPV may have evolved molecular mechanisms to impair host adaptive immunity and, more specifically, T-cell memory. Recent studies have shown that hMPV can interfere with superantigen-induced T-cell activation by infecting conventional dendritic cells (DCs). Here, we show that hMPV infects mouse DCs in a restricted manner and induces moderate maturation. Nonetheless, hMPV-infected DCs are rendered inefficient at activating naive antigen-specific CD4(+) T cells (OT-II), which not only display reduced proliferation, but also show a marked reduction in surface activation markers and interleukin-2 secretion. Decreased T-cell activation was not mediated by interference with DC-T-cell immunological synapse formation as recently described for the human respiratory syncytial virus (hRSV), but rather by soluble factors secreted by hMPV-infected DCs. These data suggest that although hMPV infection is restricted within DCs, it is sufficient to interfere with their capacity to activate naive T cells. Altogether, by interfering with DC function and productive priming of antigen-inexperienced T cells, hMPV could impair the generation of long-term immunity.
Authors:
Pablo F Céspedes; Pablo A Gonzalez; Alexis M Kalergis
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Immunology     Volume:  139     ISSN:  1365-2567     ISO Abbreviation:  Immunology     Publication Date:  2013 Jul 
Date Detail:
Created Date:  2013-06-14     Completed Date:  2013-08-19     Revised Date:  2014-07-01    
Medline Journal Info:
Nlm Unique ID:  0374672     Medline TA:  Immunology     Country:  England    
Other Details:
Languages:  eng     Pagination:  366-76     Citation Subset:  IM    
Copyright Information:
© 2013 John Wiley & Sons Ltd.
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MeSH Terms
Descriptor/Qualifier:
Animals
Antigens / immunology*
Child
Cytokines / immunology,  metabolism
Dendritic Cells / cytology,  immunology*,  metabolism,  virology*
Humans
Lymphocyte Activation / immunology*
Metapneumovirus / immunology,  pathogenicity*
Mice
Mice, Inbred BALB C
Mice, Inbred C57BL
Respiratory Tract Infections / immunology
T-Lymphocytes / immunology*
Chemical
Reg. No./Substance:
0/Antigens; 0/Cytokines
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