| Human mesenchymal stem cells and biomaterials interaction: a promising synergy to improve spine fusion. | |
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MedLine Citation:
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PMID: 22421891 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: Spine fusion is the gold standard treatment in degenerative and traumatic spine diseases. The bone regenerative medicine needs (i) in vitro functionally active osteoblasts, and/or (ii) the in vivo induction of the tissue. The bone tissue engineering seems to be a very promising approach for the effectiveness of orthopedic surgical procedures, clinical applications are often hampered by the limited availability of bone allograft or substitutes. New biomaterials have been recently developed for the orthopedic applications. The main characteristics of these scaffolds are the ability to induce the bone tissue formation by generating an appropriate environment for (i) the cell growth and (ii) recruiting precursor bone cells for the proliferation and differentiation. A new prototype of biomaterials known as "bioceramics" may own these features. Bioceramics are bone substitutes mainly composed of calcium and phosphate complex salt derivatives. METHODS: In this study, the characteristics bioceramics bone substitutes have been tested with human mesenchymal stem cells obtained from the bone marrow of adult orthopedic patients. RESULTS: These cellular models can be employed to characterize in vitro the behavior of different biomaterials, which are used as bone void fillers or three-dimensional scaffolds. CONCLUSIONS: Human mesenchymal stem cells in combination with biomaterials seem to be good alternative to the autologous or allogenic bone fusion in spine surgery. The cellular model used in our study is a useful tool for investigating cytocompatibility and biological features of HA-derived scaffolds. |
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Authors:
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G Barbanti Brodano; E Mazzoni; M Tognon; C Griffoni; M Manfrini |
Publication Detail:
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Type: In Vitro; Journal Article; Research Support, Non-U.S. Gov't Date: 2012-03-16 |
Journal Detail:
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Title: European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society Volume: 21 Suppl 1 ISSN: 1432-0932 ISO Abbreviation: Eur Spine J Publication Date: 2012 May |
Date Detail:
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Created Date: 2012-04-24 Completed Date: 2012-11-06 Revised Date: 2013-05-20 |
Medline Journal Info:
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Nlm Unique ID: 9301980 Medline TA: Eur Spine J Country: Germany |
Other Details:
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Languages: eng Pagination: S3-9 Citation Subset: IM |
Affiliation:
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Oncologic and Degenerative Spine Surgery Department, Istituto Ortopedico Rizzoli, G C Pupilli 1, 40136 Bologna, Italy. giovanni.barbantibrodano@ior.it |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Biocompatible Materials
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therapeutic use* Bioengineering / methods Bone Substitutes / therapeutic use* Cell Communication / physiology Cell Differentiation / physiology Cell Proliferation Cell Survival / physiology Cells, Cultured Ceramics* Humans Mesenchymal Stem Cell Transplantation Mesenchymal Stromal Cells / cytology*, physiology Models, Biological Spinal Diseases / surgery* Spinal Fusion / methods* Tissue Scaffolds* |
| Chemical | |
Reg. No./Substance:
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0/Biocompatible Materials; 0/Bone Substitutes; 0/Ceramics |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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